Method for typing human leukocyte antigens

Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – Molecular bilayer structure

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435 7, 435 34, G01N 3316, A61K 4300

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active

042658730

ABSTRACT:
A cellular method for typing lymphocyte defined human leukocyte antigens by utilizing human blood leukocytes which have been sensitized to proliferatively respond to the secondary stimulus of the leukocyte antigens to which they have been sensitized. The sensitization is accomplished by incubating, in vitro, in a mixed leukocyte culture, the leukocytes to be sensitized with leukocytes differing by only a single major histocompatibility complex haplotype or a single HLA-D antigenic determinant.

REFERENCES:
patent: 3900461 (1975-08-01), Wilson et al.
Bach, Radioisotopes in Medicine: In Vitro Studies, U.S. Atomic Energy Commission, Jun. 1968, pp. 579-588.
Hirschberg et al., Chemical Abstracts, vol. 80, No. 21, May 27, 1974, p. 297, abstract No. 119104d.
Sheehy et al., Science, vol. 188, No. 4195, Jun. 27, 1975, pp. 1308-1310.

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