Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1995-06-06
1998-07-21
Stucker, Jeffrey
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514315, 514326, A61K 3800, A01N 4340
Patent
active
057835632
ABSTRACT:
A method is disclosed for treatment or prophylaxis of venous thrombosis employing the peptide HOOC--CH.sub.2 --(R)Cgl--aze--Pab or a stereoisomer thereof or a physiologically acceptable salt thereof.
REFERENCES:
patent: 4346078 (1982-08-01), Bajusz et al.
patent: 4568636 (1986-02-01), Svendsen
patent: 4703036 (1987-10-01), Bajusz et al.
patent: 4977168 (1990-12-01), Bernat et al.
patent: 5037819 (1991-08-01), Han
patent: 5110812 (1992-05-01), Han
patent: 5187157 (1993-02-01), Kettner et al.
patent: 5260307 (1993-11-01), Ackerman et al.
patent: 5273982 (1993-12-01), Alig et al.
patent: 5583146 (1996-12-01), Kimball et al.
Malek et al., "Palladium-catalyzed synthesis of Cinnamylamides", J. Org. Chem. 47(27) : 5395-5397, 1982.
Malek, et al. Chem. Abs. 98: 16353, 1983.
Chung et al. J. Organic Chem. 1: 270-275.
Glusa et al. "The influence of benzamidine derivatives on human platelet function," Thrombosis et Diathesis Haemorrhagica 31: 172-178, 1974.
Anderson and Lok, J. Organic Chem. 37:3953, 1972.
Persson et al. Thorax 47; 993-1000, 1992.
Salomonson et al., Am. Rev. Resp. Dis. 146: 1535-1542, 1992.
Markwardt et al. Biochem. Pharm 23: 2247-2256, 1974.
Jackson et al. "Pharmacological Assessment of the Antithrombotic Activity of the Peptide Thrombin Inhibitor. . . ", J. of Pharm. Exp. Ther. 261: 546-552, 1992.
Knabb et al. "In Vivo Characterization of a New Synthetic Thrombin Inhibitor", Thrombosis and Haemostasis, 67(1): 56-59, 1992.
Bajusz et al. "Inhibition of Thrombin with H- and Boc-D-Phe-Pro-Agm," Chem. Abs. 99: 205609w, 1983.
Klement et al. "The Effect of Thrombin Inhibitors on Tissue Plasminogen Activator Induced Thrombolysis in a Rat Model", Thrombosis and Haemostastis, 68(1): 64-68, 1992.
Marki et al., "The Anticoagulant and Antithrombotic Properties of Hirudins", Thrombosis and Haemostasis, 64(3): 344-348, 1990.
Broersma et al., "The Effect of Thrombin Inhibition in a Rat Arterial Thrombosis Model", Thrombosis Research, 64: 405-412, 1991.
Stewart et al: "Solid Phase Peptide Synthesis," Pierce Chemical Company, pp. 18-20 (with appendix).
Bajusz: "Interaction of Trypsin-like Enzymes With Small Inhibitors," pp. 277-298, Symposia Biologica Hungarica 25 (1984).
Antonsson Karl Thomas
Bylund Ruth Elvy
Gustafsson Nils David
Nilsson Nils Olov Ingemar
Astra Aktiebolag
Park Hankyel T.
Stucker Jeffrey
LandOfFree
Method for treatment or prophylaxis of venous thrombosis does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for treatment or prophylaxis of venous thrombosis, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for treatment or prophylaxis of venous thrombosis will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1647226