Method for treatment of premenstrual syndrome

Details Method for treatment of premenstrual syndrome Method for treatment of premenstrual syndrome

1988-01-13

1990-10-16

Lipovsky, Joseph A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

514552, A61K 3156, A61K 3123

Patent

active

049635409

ABSTRACT:
A pharmaceutical composition suitable for oral administration comprises micronized progesterone in an oil vehicle which is high in glycerides of polyunsaturated fatty acids. Micronized progesterone particles suspended in such an oil vehicle are absorbed more readily into the bloodstream and achieve high progesterone blood serum levels. The pharmaceutical composition according to the invention can be readily formulated into capsules and administered for the treatment of premenstrual syndrome.

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patent: 4512986 (1985-04-01), Reel et al.
Chemical Abstracts, vol. 52 (1958), #17632g, Middendorf.
Morville et al., J. Gyn. Obst. Biol. Repr., 1982, 11, 355-363.
Gonzalez, JAMA, Apr. 10, 1981, vol. 245, No. 14, p. 1394.
Ottosson et al., Acta. Obstet. Gynecol. Scand., 63:577-579, (1984).
Dennerstein et al., British Medical Journal, vol. 290, pp. 1617-1621, Jun. 1, 1985.
Reid and Yen, Am. J. Obstet.Gynecol., vol. 139, No. 1, pp. 85-104 (1981), at 87.

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