Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1994-08-01
1996-03-12
Jordan, Kimberly
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514899, A61K 3135
Patent
active
054986311
ABSTRACT:
A method is provided for preventing or treating symptoms of menopause, premenstrual syndrome, or a condition resulting from reduced levels of endogenous estrogen, by administering to the woman an effective amount of an isoflavonoid. The invention also features a therapeutic dietary product, containing isoflavonoids, for preventing or treating symptoms of conditions resulting from reduced or altered levels of endogenous estrogen.
REFERENCES:
patent: 3864362 (1975-02-01), Feuer et al.
Setchell et al., "Mammalian Lignans and Phyto-oestrogens Recent Studies on their Formation, Metabolism and Biological Role in Health and Disease," Role of the Gut Flora in Toxicity and Cancer, pp. 315-345 (1988).
Goldin et al., "The relationship between estrogen levels and diets of Caucasian American and Oriental immigrant women.sup.1-3," Am. J. Clin. Nutr., 1986:44:945-53 (1986).
Adlercreutz, "Urinary execretion of lignans and isoflavonoid phytoestrogens in Japanese men and women consuming a traditional Japanese diet.sup.1-4," Am. J. Clin. Nutr., 1991:54:1093-1100 (1991).
Adlercreutz et al., "Determination of Urinary Lignans and Phytoestrogen Metabolites, Potential Antiestrogens and Anticarcinogens, in Urine of Women on Various Habitual Diets," J. Steroid Biochem., 1986:25:791-797 (1986).
Adlercreutz et al., "Isotope dilution gas chromatographic-mass spectrometric method for the determination of lignans and isoflavoniods in human urine, including . . . ," Clinica Chimica Acta, 199 (1991) 263-278.
Fotsis et al., "The Multicomponent Analysis of Estrogens in Urine by Ion Exchange Chromatography and GC-MS-I. Quantitation of Estrogens After Initial . . . ," J. Steroid Biochem., 1987:28:203-213 (1987).
"Dietary phyto-oestrogens and the menopause in Japan," The Lancet, 1992:339:1233 (1992).
Aldercreutz Herman
Goldin Barry R.
Gorbach Sherwood L.
Jordan Kimberly
Tufts University School of Medicine
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