Method for treatment of mast cell-mediated dermatologic disorder

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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A61K 3144

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active

049238752

ABSTRACT:
A method of treating human or animal patients suffering from mast cell-mediated dermatological disorders comprising the administration to the affected skin areas of a topical composition comprising from about 0.01 to about 10% by weight of the narcotic antagonist nalmefene or one of its salts or esters in a pharmaceutically inert topical vehicle. Compositions suitable for use in such methods include solutions, aerosols, creams, gels, ointments and lotions. The compositions may be applied to the affected areas from 1 to about 6 times daily.

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Dixon et al., J. Pharm. Sci., 73:1645-1646 (1984).
Dixon et al., Clin. Pharmacol. Ther., 39:49-53 (1986).
Thornton and Losowsky, Brit. Soc. Gastroenterology, Abstract from Spring Meeting (3/23-3/25/88).
Thornton and Losowsky, Br. Med. J., 297:1500-1504 (1988).

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