Method for treatment of Lupus nephritis

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Conjugate or complex

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514885, A61K 31045

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active

058372563

ABSTRACT:
It has been found that by administering secoisolariciresinol substantially pure form to a human or non-human animal, lupus nephritis can be controlled. The secoisolariciresinol (Seco) may be used per se or in the form of secoisolariciresinol diglucoside (SDG). Both compounds may be extracted from flaxseed and the SDG converts to Seco in the gut of a human or animal.

REFERENCES:
Bakke, JE and Klosterman, HJ: "A New Diglucoside From Flaxseed" Proc. North Dakota Acad. Sci. 10, 18-22, 1956.
Klosterman, HJ and Smith, F: "The Isolation of .beta.-Hydroxy-.beta.-Methylglutaric Acid From the Seed of Flax", J. Am. Chem. Soc. 76, 1229-1230, 1954.
MacRae, WD and Towers, GHN: "Biological Activites of Lignans", Phytochemistry, vol. 23, No. 6, pp. 1207-1220, 1984.
Harris, RK and Haggerty, WJ: "Assays for Potentially Anticarcinogenic Phytochemicals in Flaxseed", Cereal Foods World, vol. 38, No. 3, pp. 147-151, 1993.
Bambagiotti-Alberti, M et al.,: "Revealing the Mammalian Lignan Precursor Secoisolariciresinol Digucloside in Flax Seed by Ionspray Mass Spectrometry", Rapid Communications in Mass Spectrometry, vol. 8, pp. 595-598, 1994.
Obermeyer, WR et al.,: "Chemical Studies of Phytoestrogens in Flas and Chaparral", Society for Experimental Biology and Medicine, pp. 6-12, 1995.

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