Method for treatment of lower gastrointestinal tract disorders

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

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A61K 3170

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active

052293742

ABSTRACT:
This invention relates to the novel use of N-acetyl glucosamine for the treatment of gastrointestinal tract disorders by restoring and maintaining the integrity and normal function of the gastrointestinal tract. A method of treating gastrointestinal mucous membrane disorder in a human being comprising feeding the human being a therapeutic amount of N-acetyl glucosamine on a periodic basis.

REFERENCES:
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patent: 4590067 (1986-05-01), Meisner
Olaison et al., "Abnormal Intestial Permeability in Crohn's Disease", Scand. J. Gastroenterol., 25: 321-328, 1990.
Hollander et al., "Decreased Intestinal Permeability in Patients with Crohn's Disease and Their Relatives", Annals of Internal Medicine, 105: 883-885, 1986.
Burton et al., "Decreased Incorporation of .sup.14 C-Glucosamine Relative to .sup.3 H-N-Acetyl Glucosamine in the Intestinal Mucosa of Patients with Inflammatory Bowel Disease", Amer. Journal of Gastroenterology, vol. 78, No. 1, pp. 19-22, 1983.
Greenspan et al., "Oral Manifestations of Disease", Harrison's Principles of Internal Medicine, 12th ed., Ch. 41, 1991, McGraw-Hill.
Schloss, "Extraintestinal Manifestations", Idiopathic Inflammatory Bowel Disease, Thomson A. B. R. ed., M.O.M. Printers, Ottawa, 1982, Ch. 23.
Umetsu et al., "Effect of Proglumide on Glycoprotein Synthesis in Aspirin-Induced Gastric Erosions in Rats", European Journal of Pharmacology, 69:69-77, 1980.

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