Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1989-02-01
1990-09-11
Lee, Lester L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 2, 514 12, 530331, A61K 3702
Patent
active
049563440
ABSTRACT:
A method for the treatment of hyperproliferative benign or malignant lesions in the large intestinal epithelium is provided.
The method comprises administering the tripeptide L-pyroglutamyl-L-histidyl-glycine of the formula: ##STR1## in which the pyroglutamyl and histidyl moieties are of the L-configuration.
REFERENCES:
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Levine et al., Proceedings of AALR, vol. 27, (1986), p. 211.
May et al., American Physiological Society, 241, pp. 520-529 (1981).
Sassier et al., Cell Tissue Kinet., vol. 13, pp. 251-261, (1980).
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Tufton, Cell Tissue Kinet., vol. 6, pp. 211-216, (1973).
Brugal et al., Cell Tissue Kinet., vol 8, pp. 171-187, (1975).
Kanagalingan et al., Chalones, Houck (ed) Amsterdam, Oxford, N.Y., North-Holland and Am. Elsevier, pp. 459-482 (1976).
Edminson Paul D.
Fossli Tellef
Reichelt Karl L.
Skraastad Oyvind
Hafslund Nycomed A/S
Lee Lester L.
Weissendorf T.
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