Method for treatment of insulin resistance

Details Method for treatment of insulin resistance Method for treatment of insulin resistance

1996-03-08

1998-03-10

Chan, Christina Y.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 78, 436501, G01N 3350, G01N 3368

Patent

active

057260273

ABSTRACT:
A screening method for identifying compositions which affect the binding of protein tyrosine phosphatase 1B (PTP1B) to phosphorylated insulin receptor is provided. This method measures a composition's ability to inhibit binding of PTP1B to the .beta.-subunit of the insulin receptor rather than phosphatase activity in general. Also provided are specific phosphopeptides which affect the binding of protein tyrosine phosphatase 1B (PTP1B) to phosphorylated insulin receptor.

REFERENCES:
Liotta, AS et al. J. Biol. Chem. 269(37):22996-23001. Sep. 16, 1994.
Burke, TR et al. Biochem. Biophys. Res. Comm. 204(1):129-134. Oct. 14, 1994.
Kole, HK et al. Biochem. Biophys. Res. Comm. 209(3):817-822 Apr. 26, 1995.
Burke, TR et al. J. Med. Chem. 39(5): 1021-1027. Mar. 1, 1996.

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