Method for treatment of human eye disease

Details Method for treatment of human eye disease Method for treatment of human eye disease

1978-08-11

1980-09-02

Fagelson, Anna P.

Drug, bio-affecting and body treating compositions

Nonspecific immunoeffector, per se ; or nonspecific...

Bacterium or component thereof or substance produced by said...

424 87, 424 92, 435859, A61K 3134, C12K 100

Patent

active

042206570

ABSTRACT:
Sterile aqueous humor from patients afflicted with the disease endogenous uveitis contains a previously unreported pathogenic microorganism, Micromyces intracellularis, which also has been found in tissue specimens from other diseases. When inoculated into an animal model (e.g., a mouse), the microorganism produces both chronic eye and systemic disease in addition to accelerated mortality and occasional psychotic animal behavior, metabolic disturbances, and neuro-muscular disorders, depending on the mode of inoculation. The animal model therefore provides the basis for a screening process to evaulate chemotherapeutic agents in the treatment of human disease. Using this animal model, a significant decrease in mortality associated with the introduction of Micromyces intracellularis is achieved by the application to the animal model of the chemotherapeutic agents d-2,2'-(ethylenediimino)-di-1-butanol, 4,4'sufonyldianiline, and 3[[(4-methyl-1-piperazinyl)-imino]methyl]-rifamycin SV. These agents are therefore effective in the treatment of diseases having as their etiological agent Micromyces intracellularis, and are particularly useful in the chemotherapy of endogenous uveitis, conjunctivitis and kerato-conjunctivitis.

REFERENCES:
patent: 3150046 (1964-09-01), Sensi
patent: 3342810 (1967-09-01), Maggi
Alexander-Jackson, Growth, vol. 18, 1954 pp. 37-51.
Livingston, Ann, N.Y. Acad. Sci. No. 1, 174 pp. 636-654.
Robson, Recent Advances in Pharm., Little, Brown & Co. 1956 pp. 268-270, 286-290.
The Stethoscope, Nov. 1974 pg. 3.

Affiliated with

Also associated with

Rating

Method for treatment of human eye disease does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for treatment of human eye disease, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for treatment of human eye disease will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1708634