Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant or stably-transformed bacterium encoding one or...
Patent
1980-04-01
1981-10-06
Fagelson, Anna P.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Recombinant or stably-transformed bacterium encoding one or...
424337, A61K 31135, A61K 3110
Patent
active
042935687
ABSTRACT:
Sterile aqueous humor from patients afflicted with the disease endogenous uveitis contains a previously unreported pathogenic microorganism, Micromyces intracellularis, which also has been found in tissue specimens from other diseases. When inoculated into an animal model (e.g., a mouse), the microorganism produces both chronic eye and systemic disease in addition to accelerated mortality and occasional psychotic animal behavior, metabolic distrubances, and neuro-muscular disorders, depending on the mode of inoculation. The animal model therefore provides the basis for a screening process to evaluate chemotherapeutic agents in the treatment of human disease. Using this animal model, a significant decrease in mortality associated with the introduction of Micromyces intracellularis is achieved by the application to the animal model of the chemotherapeutic agents d-2,2'-(ethylenediimino)-di-1-butanol, 4,4'sulfonyldianiline, and 3[[(4-methyl-1-piperazinyl)-imino]-methyl]-rifamycin SV. These agents are therefore effective in the treatment of diseases having as their etiological agent Micromyces intracellularis, and are particularly useful in the chemotherapy of endogenous uveitis, conjunctivitis and kerato-conjunctivitis.
REFERENCES:
Clinical Trends, vol. 13, Jan. 1975, pp. 1, 4 & 5.
Livingston; Ann, N. Y. Acd. Sci., vol. 174, Oct. 30, 1970, pp. 636-654.
Today's Health, Feb. 1975, p. 9.
The Stethoscope, Nov. 1974, 1 pg.
Medical Tribune, vol. 15, No. 44, Nov. 27, 1974, pp. 1, 25.
Martindale, The Extra Pharm., Pharm. Press, London, 27th ed. 1977, pp. 1499-1503.
Johnson Lewis A.
Wirostko Emil
LandOfFree
Method for treatment of human eye disease does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for treatment of human eye disease, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for treatment of human eye disease will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1206703