Drug – bio-affecting and body treating compositions – Lymphokine
Patent
1989-01-24
1991-08-06
Nutter, Nathan M.
Drug, bio-affecting and body treating compositions
Lymphokine
424 88, 436523, 436527, 210656, 210691, 210263, 530413, 502403, B01D 1508, G01N 33543, G01N 33552
Patent
active
050376497
ABSTRACT:
Patients suffering from HIV-1 infection, including both those who have and those who have not developed acquired immunodeficiency syndrome, are treated by extracorporeal removal of IgG and immune complexes. An immunoadsorbent material for removing IgG and IgG-complexes from biological fluids is prepared by covalently binding protein A to a solid-phase silica matrix. It has been found that particularly stable, high-capacity immunoadsorbents are obtained by derivatizing the silica with amino and/or carboxyl groups, and reacting the protein A with a carbodiimide at a pH in a range from 3.5 to 4.5. Binding through free hydroxyl groups may be achieved with cyanogen halides at a pH in the range from 11.0 to 11.5. After acid washing (pH 2.0-2.5) to remove non-covalently bound protein A, the immunoadsorbent may be employed in a column for therapeutic treatment of various cancers and autoimmune disorders where IgG-complexes are implicated as suppressing factors in inhibiting a normal immune response.
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Balint, Jr. Joseph P.
Jones Frank R.
IMRE Corporation
Nutter Nathan M.
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