Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Hydrolases
Patent
1995-02-21
1996-09-24
Wityshyn, Michael G.
Drug, bio-affecting and body treating compositions
Enzyme or coenzyme containing
Hydrolases
A61K 3847
Patent
active
055588638
ABSTRACT:
A method and composition are provided for treatment of herpes virus infections. The invention comprises the administration of a low level of neuraminidase protein or a derivative thereof.
REFERENCES:
Smiley, L. et al., "Binding of Complement Component C3b to Glycoprotein C is Modulated by Sialic Acid on Herpes Simplex Virus Type 1-Infected Cells," Journal of Virology, vol. 55, No. 3, pp. 857-861 (Sep. 1985).
Arora, D. J. S. et al., "In Vitro Enhancement of Human Natural Cell-Mediated Cytoxicity by Purified Influenza Virus Glycoproteins," Journal of Virology, vol. 52, No. 3, pp. 839-845 (Dec. 1984).
Yarnell, M. M. et al., "Studies of Tumour Invasion in Organ Culture--II. Effects of Enzyme Treatment," Europ. J. Cancer, vol. 5, pp. 265-269 (1969).
Tompkins, W. A. F. et al., "Neuraminidase Reversal of Resistance to Lysis of Herpes Simplex Virus-Infected Cells by Antibody and Complement," The Journal of Immunology, vol. 116, No. 2, pp. 489-495 (Feb. 1976).
Varghese, J. N. et al., "Structure of the influenza virus glycoprotein antigeuraminidase at 2.9 .ANG. resolution," Nature, vol. 303, pp. 35-40 (May 5, 1983).
Berwick, L. et al., "Some Chemical Factors in Cellular Adhesion and Stickiness," Cancer Research, vol. 22, pp. 982-987 (Sep. 1962).
Hatano, H. et al., "Effect of neuraminidase on Fc and C3b receptors on rabbit corneal cells infrects with herpes simplex virus," Current Eye Research, vol. 6, No. 1, pp. 53-57 (1987).
Boyd, R. F. et al., "Basic Medical Microbiology," Basic Medical Microbiology--Second Edition, p. 527.
Santoli, D. et al., "Mechanisms of Activation of Human Natural Killer Cells Against Tumor and Virus-Infected Cells," Immunological Review, vol. 44, pp. 125-163.
Arnheiter, H. et al., "Host Gene Influence on Interferon Action in Adult Mouse Hepatocytes: Specificity for Influenza Virus," Virology, vol. 103, 11-20 (1980).
Miller, J. B., "Treatment of Active Herpes Virus Infections with Influenza Virus Vaccine," Annals of Allergy, vol. 42, pp. 295-305 (May 1979).
Stein-Streilein, J. et al., "In Vivo Treatment of Mice and Hamsters with Antibodies to Asialo GM1 Increases Morbidity and Mortality to Pulmonary Influenza Infection," The Journal of Immunology, vol. 135, No. 4, pp. 1435-1441 (Feb. 15, 1986).
Yasukawa, M. et al., "Autologous Herpes Simplex Virus-Infected Cells are Lysed by Human Natural Killer Cells," The Journal of Immunology, vol. 131, No. 4, pp. 2011-2016 (Oct. 1983).
Ching, C. et al., "Natural Killing of Herpes Simplex Virus Type 1-Infected Target Cells: Normal Human Responses and Influence of Antiviral Antibody," Infection and Immunity, vol. 26, No. 1, pp. 49-56 (Oct. 1979).
St. Geme, Jr., J. W. et al., "Impaired Cellular Resistance to Herpes-Simplex Virus in Wiskott-Aldrich Syndrome," The New England Journal of Medicine, vol. 273, No. 5, pp. 229-234.
Rawls, W. E., "Herpes Simplex Virus Infections: Type 1 and Type 2 Viruses," Laboratory Diagnosis of Viral Infections--Edited by Edwin H. Lennette, Chapter 19, pp. 313-340.
"The Epstein-Barr Virus", edited by M. A. Epstein et al., published by Springer-Verlag, pp. 298-320 (1979).
Dajer, T., "Herpes Key," Discover, p. 20 (Nov. 1990).
Herring, T. "A Salivary Herpesvirus Interacts with HIV,"ASM News, vol. 56, No. 10, pp. 522-523 (1990).
Trinchieri, G. et al., "Anti-Viral Activity Induced by Culturing Lymphocytes with Tumor-Derived or Virus-Transformed Cells," J. Exp. Med., pp. 1299-1313.
Djeu, J. Y. et al., "Positive Self Regulation of Cytotoxicity in Human Natural Killer Cells by Production of Interferon upon Exposure to Influenza and Herpes Viruses," Journal of Experimental Medicine, vol. 156, pp. 1222-1234 (Oct. 1982).
Nahmias, A. J. et al., "Infection with Herpes-Simplex Viruses 1 and 2," The New England Journal of Medicine, vol. 289, No. 13, pp. 667-674 (Sep. 27, 1973).
McTaggart, S. P. et al., "Fc Receptors Inducted by Herpes Simplex Virus--I. Biologic and Biochemical Properties," The Journal of Immunology, vol. 121, No. 2, pp. 727-730 (Aug. 1978).
Levy, J. A. et al., "Human Herpevirus 6 Inhibits Human Immunodeficiency Virus Type 1 Replication in Cell Culture," Journal of Clinical Microbiology, vol. 28, pp. 2362-2364 (Oct. 1990).
Lennette, E. T., "Diagnosis of Epstein-Barr Virus Infections," Chapter 16, pp. 257-271.
Welsh, R. M., "Natural Cell-Medicated Immunity During Viral Infections," Natural Resistance to Tumors and Viruses, edited by O. Haller, published by Springer-Verlag, pp. 83-106.
Haller, O., "Inborn Resistance of Mice to Orthomyxoviruses," Current Topics in Microbiology and Immunology, edited by W. Henle, pp. 25-52.
Strauss, S. E. et al., "Acyclovir treatment of the chronic fatigue syndrome: Lack of efficacy in a placebo-controlled trial," N. Engl. J. Med., Abstract: 319 (26), pp. 1692-1698 (1988) Abstract.
Lung, M. L. et al., "Detection of Distinct Epstein-Barr Virus Genotypes in NPC Biopsies from Southern Chinese and Caucasians," Int. J. Cancer, vol. 52 (1), pp. 34-37 (1992) Abstract.
Levine, P. H. et al., "Clinical Epidemiologic and Virologic Studies in Four Clusters of the Chronic Fatigue Syndrome," Arch Intern Med., vol. 152 (8), pp. 1611-1616, (1992) Abstract.
Kline Ellis L.
McAlhaney Walter W.
Molecular Rx, Inc.
Wityshyn Michael G.
Witz Jean C.
LandOfFree
Method for treatment of herpes virus infections does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for treatment of herpes virus infections, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for treatment of herpes virus infections will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1927122