Method for treatment of gastric ulcers and ulcers induced by...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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Details

C514S254110, C514S320000, C514S456000

Reexamination Certificate

active

07855200

ABSTRACT:
The present invention relates to methods of usingOroxylum indicumas a rich source for flavanoid compounds having mucoprotective and antigastric ulcer properties, and containing Oroxylin A, Chrysin and Baicalein.

REFERENCES:
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patent: 5399584 (1995-03-01), Ares et al.
patent: 5464620 (1995-11-01), Zhao
patent: WO 98/04541 (1998-02-01), None
patent: WO 2004/089392 (2004-10-01), None
patent: WO 2005/011671 (2005-02-01), None
International Search Report and Written Opinion, Jun. 8, 2007.
K. Suresh Babu et al, Bioorg. Med. Chem. Lett. 15 (2005) 3953-3956, “Synthesis and in vitro study of novel 7-O-acyl derivatives of Oroxylin A as antibacterial agents.”.
K. Suresh Babu et al, Bioorg. Med. Chem. Lett. 16 (2006) 221-224, “Synthesis and biological evaluation of novel C (7) modified chrysin analogues as antibacterial agents.”
L. J. Chen et al, J. Chromatogr. A 988 (2003) 95-105, “Isolation and identification of four flavonoid constituents from the seeds ofOroxylum indicumby high-speed counter-current chromatopraphy.”.
L. J. Chen et al, J. Chromatogr. A 1063 (2005) 241-245, “Comparison of high-speed counter-current chromatography instruments for the separation of the extracts of the seeds ofOroxylum indicum.”
G. Flamini et al, Phytochemistry 61 (2002) 433-437, “Flavonoid glycosides fromCentaurea pseudoscabiosasubsp.pseudoscabiosafrom Turkey.”.
F. Tombola et al, FEBS Letters 543 (2003) 184-189, “Plant polyphenols inhibit VacA, a toxin secreted by the gastric pathogenHelicobacter pylori.”
M. Khandhar et al, Pharmaceutical Biology (2006) vol. 44, No. 5, 363-370, “Antiulcer Activity of the Root Bark ofOroxylum indicumAgainst Experimental Gastric Ulcers.”

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