Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai
Patent
1997-08-29
1999-11-23
Kulkosky, Peter F.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ester doai
514923, 424449, A61K 31235
Patent
active
059901624
ABSTRACT:
A method is provided to treat a human afflicted with chronic fatigue syndrome or fibromyalgia syndrome by the administration of certain butyrate derivatives.
REFERENCES:
patent: 4599355 (1986-07-01), Kluger et al.
patent: 4738985 (1988-04-01), Kluger et al.
patent: 5594030 (1997-01-01), Conte et al.
The Facts About Chronic Fatigue Syndrome, Centers for Disease Control and Prevention, National Center for Infectious Diseases, Atlanta, GA, 1-21, (Mar. 1995).
Bennett, R.M., et al., "Hypothalamic-Pituitary-Insulin-like Growth Factor-I Axis Dysfunction in Patients with Fibromyalgia", The Journal of Rheumatology, 24, 1384-1389, (1997).
Buchwald, D., et al., "Insulin-like Growth Factor-I (Somatomedin C) Levels in Chronic Fatigue Syndrome and Fibromyalgia", The Journal of Rheumatology, 23, 739-742, (1996).
Entholzner, E., et al., "EEG Changes During Sedation with Gamma-Hydroxybutyric Acid", Anaesthesist, 44 (5), 345-350, (1995).
Fukuda, K., et al., "Management Strategies for Chronic Fatigue Syndrome", Federal Practitioner, 9 pgs, (Jul. 1995).
Goldenberg, D.L., et al., "A Randomized, Controlled Trial of Amitriptyline and Naproxen in the Treatment of Patients With Fybromyalgia", Arth. Rheum., 29, 1371, (1986).
Goldenberg, D.L., et al., "Fibromyalgia and Chronic Fatigue Syndrome: Are they the Same?", J. Muscoloskel Med., 7, 19, (1990).
Goldenberg, D.L., et al., "High Frequency of Fibromyalgia in Patients with Chronic Fatigue Seen in a Primary Care Practice", Arth. Rheum., 33 (3), 381-387, (Mar. 1990).
Griep, E.N., et al., "Pituitary Release of Growth Hormone and Prolactin in the Primary Fibromyalgia Syndrome", The Journal of Rheumatology, 21, 2125-2130, (1994).
Mamelak, M., et al., "The Effects of Gamma-Hydroxybutyrate on Sleep", Biol. Psychiatry, 12 (2), 273-288, (1977).
Moldofsky, H.D., et al., "A Chronbiologic Theory of Fibromyalgia", J. Muscoloskel. Pain, 1, 49, (1993)
Moldofsky, H.D., et al., "Musculoskeletal Symptoms and Non-REM Sleep Disturbance in Patients with "Fibrositis Syndrome" and Healthy Subjects", Psychosoma. Med., 37, 341, (1975).
Pellegrino, M.J., et al., "Familial Occurrence of Primary Fibromyalgia", Arch. Phys. Med. Rehab., 70, 61, (1989).
Schaefer, K.M., "Sleep Disturbances and Fatigue in Women With Fibromyalgia and Chronic Fatigue Syndrome", JOGNN, 24 (3), 229-233, (Mar./Apr. 1995).
Scharf, M.B., et al., "Current Pharmacologic Management of Narcolepsy", American Family Physician, 38 (1), 143-148, (Jul. 1988).
Scharf, M.B., et al., "The Effects and Effectiveness of y-Hydroxybutyrate in Patients with Narcolepsy", J. Clin. Physchiatry, 46 (6), 222-225, (1985).
Smythe, H.A., "Studies of Sleep in Fibromyalgia: Techniques, Clinical Significance, and Future Directions", British Journal of Rheumatology, 34, 897-900, (1995).
Van Cauter, E., et al., "Simultaneous Stimulation of Slow-Wave Sleep and Growth Hormone Secretion by Gamma-hydroxybutyrate in Normal Young Men", J. Clin. Invest., 100 (3), 745-753, (1997).
Yamada, Y., et al., "Effect of Butyrolactone and Gamma-Hydroxybutyrate on the EEG and Sleep Cycle in Man", Electroenceph. clin. Neurophysiol., 22, 558-562, (1967).
Yunus, M.B., et al., "A Controlled Study of Primary Fibromyalgia Syndrome: Clinical Features and Association with Other Functional Syndromes", J. Rheumatol., 16, 62, (1989).
Broughton, R., et al., "The Treatment of Narcolepsy-Cataplexy with Nocturnal Gamma-Hydroxybutyrate", Le Journal Canadian des Sciences Neurologiques, 6 (1), 285-289, (1979).
Mamelak, M., et al., "Treatment of Narcolepsy with y-Hydroxybutyrate. A Review of Clinical and Sleep Laboratory Findings", Sleep, 9(1), 285-289, (1986).
Montplaisir, J., et al., "Le Gamma-hydroxybutyrate de Sodium (GHB) dans le Traitement de L'hypersomnie Essentielle", Can. J. Psychiatry, 26, 162-166, (1981).
CA 126:99858 Van Cauter et al Jun. 1996.
CA 127:200274 Van Cauter et al 1997.
CA 87:112300 1977 M. Mamelak et al.
CA 123:188258 (1995).
Kulkosky Peter F.
Orphan Medical, Inc.
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