Method for treatment of cataract with radical scavenger

Details Method for treatment of cataract with radical scavenger Method for treatment of cataract with radical scavenger

1996-08-16

1999-02-23

Killos, Paul J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A01N 4364

Patent

active

058744550

ABSTRACT:
The invention provides a method for treatment of cataract which comprises administering to a subject in need of such treatment, a radical scavenger in an amount effective in treatment of cataract selected from the group consisting of a reducing thiol derivative, or a disulfide derivative and a sulfide derivative thereof, and a pharmaceutical composition for treatment of cataract which comprises an anti-cataract agent containing a radical scavenger and fine particles, such as emulsions, nanocapsules, alubmin microspheres and liposomes, which carries an anti-cataract agent and has a lipophilic and positively charged phase on the surface thereof.

REFERENCES:
patent: 4347371 (1982-08-01), Iwao et al.
patent: 4870101 (1989-09-01), Ku et al.
patent: 5035878 (1991-07-01), Borch et al.
patent: 5061734 (1991-10-01), Mao et al.
patent: 5124154 (1992-06-01), Babcock et al.
patent: 5174988 (1992-12-01), Mautone et al.
patent: 5185152 (1993-02-01), Peyman
patent: 5332582 (1994-07-01), Babcock et al.
patent: 5338545 (1994-08-01), Clark et al.
Ito, Y., et al, Preparation of Liposomes Containing Disulfiram and Application of it as an Anti-cataract Agent, Abstract of Int. CCRG Congress, Bethesda, MD, Nov. 7-10, 1993, p. 55.
Arai, K., et al, J. Biol. Chem., 262, 16969-16972 (1987).
Arai, K., et al, Biochem. Biophys. Acta, 924, 292-296 (1987).
Epstein, D. L, et al, Invest. Ophthamol. 9, 629-638 (1970).
Merriam, G. R., et al, Radiat. Res., 62, 488-497 (1975).
Gupta, V. D., Am. J. Hosp. Pharm., 38, 363-364 (1981).
Agarwal, R. A., et al, Res. Comm. Chem. Pathol. Pharmacol. 42, 293-310 (1983).
Sakurai, T., et al, FEBS Letters, 236, 406-410 (1988).
Morimoto, K., et al, Arch. Int. Pharmacodyn., 293, 7-13 (1988).
Varma, S. D., et al, Ophthamic. Res. 14, 167-175 (1982).
Reddy, V. N., et al, Lens and Eye Toxic. Res., 6, 573-588 (1989).
Kuhnlein, U., Biochem. Biophys. Acta., 609, 75-82 (1980).
Nojima, S., et al, eds., The Liposomes, Nankodo, 1988, p. 10.

Affiliated with

Also associated with

Rating

Method for treatment of cataract with radical scavenger does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for treatment of cataract with radical scavenger, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for treatment of cataract with radical scavenger will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-307448