Method for treatment of cancer by oral administration of modifie

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514 61, 536 2, A61K 31715

Patent

active

058957847

ABSTRACT:
A method for the treatment of cancer in mammals. A subject afflicted with cancer receives by oral administration a pH modified citrus pectin which inhibits metastasis of primary tumors.

REFERENCES:
patent: 2036922 (1936-04-01), Clarke et al.
patent: 2132577 (1938-10-01), Olsen et al.
patent: 2786763 (1957-03-01), Rivoche
patent: 2791508 (1957-08-01), Rivoche
patent: 2859115 (1958-11-01), Rivoche
patent: 3023104 (1962-02-01), Battisa
patent: 3396034 (1968-08-01), Blondheim et al.
patent: 3573058 (1971-03-01), Tiemstra
patent: 3764707 (1973-10-01), Habersberger
patent: 3946110 (1976-03-01), Hill
patent: 4241099 (1980-12-01), Tiemstra
patent: 4263334 (1981-04-01), McGinley
patent: 4264592 (1981-04-01), Xhajanka
patent: 4268533 (1981-05-01), Williams et al.
patent: 4305970 (1981-12-01), Moran et al.
patent: 4370354 (1983-01-01), Leipold
patent: 4389426 (1983-06-01), Reissmann et al.
patent: 4430349 (1984-02-01), Malone et al.
patent: 4568673 (1986-02-01), Brooks et al.
patent: 4672034 (1987-06-01), Rombouts et al.
patent: 4686106 (1987-08-01), Ehrlich et al.
patent: 4689322 (1987-08-01), Kulbe et al.
patent: 4737582 (1988-04-01), Goldman et al.
patent: 4774095 (1988-09-01), Kleinschmidt et al.
patent: 4800096 (1989-01-01), DiGiovacchino et al.
patent: 4828396 (1989-05-01), Singer et al.
patent: 4844922 (1989-07-01), Uemura et al.
patent: 4857512 (1989-08-01), Wagner et al.
patent: 4882187 (1989-11-01), Izzo et al.
patent: 4904697 (1990-02-01), Sunkara et al.
patent: 4911946 (1990-03-01), Singer et al.
patent: 4917915 (1990-04-01), Cain et al.
patent: 4950655 (1990-08-01), Bachmann
patent: 4956193 (1990-09-01), Cain et al.
patent: 4959227 (1990-09-01), Amer
patent: 4985250 (1991-01-01), Bee et al.
patent: 4988530 (1991-01-01), Hoersten et al.
patent: 5004758 (1991-04-01), Boehm et al.
patent: 5011701 (1991-04-01), Baer et al.
patent: 5071970 (1991-12-01), le Grand et al.
patent: 5100688 (1992-03-01), Cox et al.
patent: 5133979 (1992-07-01), Clarke et al.
patent: 5153020 (1992-10-01), Singer et al.
patent: 5238699 (1993-08-01), King et al.
patent: 5244688 (1993-09-01), Norton
patent: 5279884 (1994-01-01), Wesdorp et al.
patent: 5324531 (1994-06-01), Hoefler et al.
patent: 5374444 (1994-12-01), Langner
patent: 5441943 (1995-08-01), McAnalley et al.
Bauer et al. "Effect of Dietary Fiber on the Induction of Colorectal Tumors and Fecal .beta.-Glucuronidase Activity in the Rat," Cancer Research 39, 3752-3756 (1979).
Goldsworthy et al. "The effect of diet on 2,6-dinotrotoluene hepatocarcinogenesis," Carcinogenesis 7, 1909-1915 (1986).
Hardman et al. "Site specific reduction in colon cancer incidence by dietary intervention," Proceedings of the American Association for Cancer Research 34, 3295 (1994).
Hsieh et al. "Changes in Cell Growth, Cyclin/Kinase, Endogenous Phosphoproteins and nm 23 Gene Expression in Human Protastic JCA-1 Cells Treated with Modified Citrus Pectin," Biochemistry and Molecular Biology International 37, 833-841 (1995).
Murai et al. "Effect of Oral Administration to Rats of Various Undigestible Saccharides on Fecal pH, Water Contents and Enzyme Actvities," Bifidobacteria Microflora 13, 91-98 (1994).
La Nouvelle Presse Medicale 9, 1710 (1980).
Murai et al., Bifidobacteria Microflora, vol. 13(2):91-98, 1994.
Bauer et al., Cancer Research, vol. 39(9):3752-3756, 1979.
Hardman et al., Proc. Annu. Meet. Am. Assoc. Cancer Res., vol. 34:A3295, 1993.
Vitaux et al., Nouv. Presse Med., vol. 9(24):1710, 1980.
English Language Abstract of JP Patent No. 63-139108.
Abstract "Modified pectin".
Peter Albersheim,"Instability of Pectin in Neutral Solutions," Biochemical and Biophysical Research Communications, vol. 1, No. 5, Nov. 1959, pp. 253-256.
Povl E. Christensen,"Methods of Grading Pectin in Relation to the Molecular Weight," Food Reaserch, vol. 19, (1954), pp. 163-165..
Peter Albersheim, Hans Neukom and Hans Deuel, "Splitting of Pectin Chain Molecules in Neutral Solutions", Archives of Biochemistry and Biophysics, vol. 90, (1960), pp. 46-51.
W.F. Dunning, "Prostate Cancer in the Rat," Natl. Cancer Inst. Mono, vol. 12, (1963), pp. 351-369.
Peter Albersheim, "a Method for Analysis of Sugars in Plant Cell Walls Polysaccharides by Gas Liquid Chromatography", Carbohydrate Reaserch, vol. 5, (1967), pp. 340-346.
D.A. Rees and A.W. Wight, "Polysaccharide Conformation. Pat Vii. Model Building Computations for .alpha.-1,4 Galacturonan and Kinking Function of L-Rhamnose Residues in Pectic Substances", J. Chem. Soc. B, (1971), pp. 1366-1372.
Gordon A. Towle and Otto Christensen, "Industrial Gums; Polysaccharides and Their Derivatives," (Eds. Roy L. Whistler and James N. BeMiller) Academic Press, New York and London, (1973), pp. 429-460.
D.A. Rees and E.J. Welsh, "Secondary and Tertiary Structure of Polysaccharides in Solutions and Gels," Angew. Chem. Int. Ed. vol. 16, (1977), pp. 214-224.
J.T. Isaacs, W.D.W. Heston, R.M. Weissmann, D.S. Coffey, "Animal models of the Hormone-sensitive and--insensitive Prostatic Adenocarcinomas, Dunning R-3327-H, R-3327-HI, R-3327-AT", Cancer Res., vol. 38 (1978), pp. 4353-4359.
Avraham Raz and Reuben Lotan, "Lectin-like Activities Associated with Human and Murine Neoplastic Cells", Cancer Research, vol. 14, Sep. 1981, pp. 3642-3647.
D. Thom, I.C.M. Dea, E.R. Morris and D.A. Powell, "Interchain Associations of Alginate and Pectins" Prog. Ed. Nutr. Sci, vol. 6, (1982), pp. 97-108.
Talila Volk, Benjamin Geiger and Avraham Raz, "Motility and Adhesive Properties of High- and Low- metastatic Murine Neoplastic Cells", Cancer Research, vol. 44, (1984), pp. 811-824.
Iwao Suzuki, Teru Itani, Naohito Ohno, Shozo Oikawa, Kichiro Sato, Toshio Miyazaki, Toshiro Yadomae, "Antitumor Activity of a Polysaccharide Fraction Extracted from Cultured Fruiting Bodies of Grifola frondosa", J. Pharm. Dyn., vol. 7, (1984), pp. 492-500.
Leonid Meromsky, Reuben Lotan and Avraham Raz, "Implications of endogenous tumor cell surface lectins as mediators of cellular interactions and lung colonization", Cancer Research, vol. 46, Oct. 1986, pp. 5270-5275.
J.T. Isaacs, W.B. Isaacs, W.F.J. Feitz, J. Scheres, "Establishment and Characterization of Seven Dunning Rat Prostatic Cancer Cell Lines and Their Use in Developing Methods for Predicting Metastatic Abilities of Prostatic Cancer'" The Prostate vol. 9, (1986), pp. 261-281.
J. Beuth, H.L. Ko, K. Oette, G. Pulverer, K. Roszkowski and G. Ulenbruck, "Inhibition of Liver Metastasis in Mice by Blocking Hepatocyte Lectins with Arabinogalactan Infusions and D-galactose", J. Cancer Res. Clin Oncol, vol. 113, (1987), pp. 51-55.
Avraham Raz, Aharon Avivi, Galit Pazerini and Pnina Carmi, "Cloning and Expression of cDNA for Two Endogenous UV-2237 Fibrosarcoma Lectin Genes", Experimental Cell Research, vol. 173, (1987), pp. 109-116.
Avraham Raz, Daguang Zhu, Victor Hogan, Nipa Shah, Tirza Raz, Rivka Karkash, Galit Pazerini and Pnina Carmi, "Evidence for the Role of 34-kDa Galactoside-binding Lectin in Transformation and Metastasis", Int. J. Cancer, vol. 46, (1990), pp. 871-877.
Edgar A. Mueller and F. Alfred Anderer, "Synergistic Action of a Plant Rhamnogaloacturonan Enhancing Antitumor Cytotoxicity of Human Natural Killer and Lymphokine-activated Killer Cells: Chemical Specificity of Target Cell Recognition", Cancer Res., vol. 50, No. 12, (1990), pp. 3646-3651.
Edgar A. Mueller and F. Alfred Anderer, "Chemical Specificity of Effector Cell/Tumor Cell Bridging by a Viscum album Rhamnogalacturonan Enhancing Cytotoxicity of Human NK Cells", Immunophamacology, vol. 19, (1990), pp. 69-77.
Hercules Incorporated, "Nature's Simple Solution to Fat Replacement--SLENDID", 1991, pp. 1-12.
Hercules Incorporated, News Release, "New Natural Fat Replacement Introduced", Sep. 23, 1991.
Hans-Joachim Gabius, "Detection and Functions of Mammalian Lectins--with Emphasis on Membrane Lectins", Biochimica et Biophysics Acta, vol. 1071, (1991), pp. 1-18.
Lance A. Liotta, Patricia S. Steeg and William G. Stetler-Stevenson, "Cancer Metastasis and Angiogenesis: an Imbalance of Positive and Negative Regulation", Cell, vol. 64, Jan. 1991, pp. 327-336.
Avraham Raz, Pnina Carmi, Tirza Raz

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Method for treatment of cancer by oral administration of modifie does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for treatment of cancer by oral administration of modifie, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for treatment of cancer by oral administration of modifie will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2247969

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.