Method for treatment of autoimmune hepatitis

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

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514 2, 514885, 514179, 530324, 530399, 552576, 4352401, A61K 3804, A61K 3156, C07K 14475, C07J 5100

Patent

active

054687292

ABSTRACT:
A method and composition for treating autoimmune hepatitis in a patient utilizes an immunomodulatory amount of T.alpha..sub.1 and an anti-inflammatory amount of a corticosteroid.

REFERENCES:
patent: 4444757 (1984-04-01), Stausser
Eichberg et al., "Effect of Thymosin Immunostimulation With and Without Corticosteroid Immunosuppression on Chimpanzee Hepatitis B Carriers", Journal of Medical Virology, 21:1, pp. 25-37, Jan. 1987.
Kurbanov, T. G., et al., "Efficacy of the Use of Tymalin in Children With Diabetes Mellitus", Probl-Endokrinol (Mosk) 1989; 35(6):7-9.
O'Brien, C. J., et al., "In Vitro Effect of TP-1 (A Calf Thymic Extract) on Suppressor T-Cell Function of Patients with Autoimmune Chronic Active Hepatitis", Int. J. Immnopharmac., vol. 10, No. 6, pp. 651-656, 1988.
Marshall, G. D., Jr. et al., "In Vivo Generation of Surppressor T Cells by Thymosin in Congenitally Athymic Nude Mice", The Journal of Immunology, vol. 126, No. 2, pp. 741-744, Feb. 1981.
Low, T. L. K., et al., "The Chemistry and Biology of Thymosin", The Journal of Biological Chemistry, vol. 254, No. 3, Feb. 10, pp. 981-986, 1979.
Hegarty, J. E., et al., "Controlled Trial of a Thymic Hormone Extract (Thymostimulin) in `Autoimmune` Chronic Active Hepatitis", Gut, 1984, 25, 279-283.
Pernice, W., et al., "Steroid Economising Effects of a Calf Thymus Extract in Three Patients with Juvenile Chronic Arthritis", Klinische Wochen-Schrift, (1983), 61:429-431.
Jacobs, R. P. et al., "Treatment of Rheumatoid Arthritis With Thymosin: Preliminary Immunologic Studies", Thymic Factor Therapy, Byrom, N. A. and Hobbs, J. R. eds., New York, Raven Press, pp. 267-276 (1984).
Goldstein et al., "Potential Role of Thymosin in The Treatment of Autoimmune Diseases", Ann. N.Y. Acad. Sci., 377:486-495 (1981).
Laskin et al., Am. J. of Med., vol. 89, 129-133, 1990.
Antiviral Agents Bulletin, vol. 4, No. 10, Oct. 1991.
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