Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector
Patent
1995-06-06
2000-03-21
Cunningham, Thomas M.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
4241851, 4241931, 4241941, 42419511, 530350, 530395, 530402, 530403, A61K 39385, A61K 39395, C07K 1618, C07K 1626
Patent
active
060399481
ABSTRACT:
Endogenous and exogenous proteins, and fragments thereof, are chemically modified outside the body of an animal so that when injected into the animal they produce more antibodies against the unmodified protein than would injection of the unmodified protein or fragment alone. The chemical modification may be accomplished by attaching the proteins or fragments to carriers such as, for example, bacterial toxoids. The chemical modification can also be accomplished by polymerization of protein fragments. Proteins which can be modified include Follicle Stimulating Hormone and Human Chorionic Gonadotropin. The modified polypeptide may be administered to animals for the purpose of contraception, abortion or treatment of hormone-related disease states and disease disorders, treatment of hormone-associated carcinomas, and to boost the animals' resistance to exogenous proteins, for example viral proteins.
REFERENCES:
patent: 2301532 (1942-11-01), Fell
patent: 2372066 (1945-03-01), Fell
patent: 2388260 (1945-11-01), Friedhelm
patent: 2744890 (1956-05-01), Wagner
patent: 3317400 (1967-05-01), Beusser
patent: 4122166 (1978-10-01), Tribble et al.
patent: 4123519 (1978-10-01), Tribble et al.
patent: 4161519 (1979-07-01), Tolwar
patent: 4179337 (1979-12-01), Davis et al.
patent: 4193982 (1980-03-01), Avrameas et al.
patent: 4201770 (1980-05-01), Stevens
patent: 4400316 (1983-08-01), Katsuragi et al.
patent: 4526716 (1985-07-01), Stevens
patent: 5006334 (1991-04-01), Stevens
B. Cinader et al., J. of Experimental Medicine, vol. 125, No. 6, pp, 105 1073 (1967).
W.E. Nixon et al., J. Lab. Clin. Med. (1971), vol. 78, No. 6, pp. 949-956.
S.J. Gross et al., Immunochemistry, vol. 5, pp. 55-65 (1968).
M. Tabachnick et al., J. of Biological Chemistry, vol. 235, 1960 pp. 1051-1054.
Currie, J. Obstet. Gynaec. Brit. Cwlth., vol. 74, pp. 845-848 (1967).
Nisula et al, Cancer Res. vol. 34, pp. 512-515 (1974).
W.R. Jones, Immunological Fertility Regulation, Blackwell Scient. Publications, Victoria, Australia (1982) , pp. 130-146, 158-171, 207-267.
Basic and Clinical Immunology, 3rd edition, pp. 44-52. Fudenberg et al. (ed), 1980.
Geysen, H. M. et al., J. Molecular Recognition, 1:32-41, Cognitive features of continuous antigen determinants, 1988.
Cunningham Thomas M.
Kremblas Francis T.
The Ohio State University
VanderVegt F. Pierre
LandOfFree
Method for treatment of antigenically modified polypeptides does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for treatment of antigenically modified polypeptides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for treatment of antigenically modified polypeptides will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-728083