Method for treatment of amyotrophic lateral sclerosis comprising

Details Method for treatment of amyotrophic lateral sclerosis comprising Method for treatment of amyotrophic lateral sclerosis comprising

1990-07-30

1993-07-20

Hollrah, Glennon H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514879, A61K 3144

Patent

active

052293947

ABSTRACT:
A method for treating ALS (Amyotrophic Lateral Sclerosis) is disclosed. The inventive method comprises the administration of controlled dosages of dextromethorphan in therapeutically effective amounts in a pharmaceutically acceptable vehicle Dextromethorphan (DMP) is a dimethylaminomethyl-substituted phenol, a sigma receptor antagonist known also as d-3-methoxy-N methylmorphinan, a d-isomer of the codeine analog, levorphanol. The inventive method has proven useful in controlling the progression of ALS in afflicted patients.

REFERENCES:
patent: 4806543 (1989-02-01), Choi
patent: 4888347 (1989-12-01), Woodruff et al.
Rowland, "Human Motor Neuron Diseases," Advances in Neurology, vol. 36, pp. 5-6 (1990).
Walker, S. O. et al. (1989), Clinical Neuropharmacology, vol. 12, pp. 322-330, 1989.
Gillberg, P. et al. Acta Neurol. Scand. 72:299-306 (1985).
Spencer, P. S. et al. Science 237:517-521 (1987).

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