Method for treatment and prevention of deficiencies of vitamins

Details Method for treatment and prevention of deficiencies of vitamins Method for treatment and prevention of deficiencies of vitamins

1992-12-29

1996-10-08

Henley, III, Raymond

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514249, 514345, A61K 3170, A61K 31495, A61K 3144

Patent

active

055631266

ABSTRACT:
A method for orally administering vitamin preparations is described which combine vitamin B.sub.12 (B.sub.12, cobalamin) and folic acid (folate), with and without pyridoxine (B.sub.6), for preventing and treating elevated serum homocysteine (HC), cystathionine (CT), methylmalonic acid (MMA), or 2-methylcitric acid (2-MCA) levels. These metabolites have been shown to be indicative of B.sub.12 and/or folic acid deficiencies. Further, it is likely that a B.sub.6 deficiency may be present with a B.sub.12 or folate deficiency. The method of the invention is also for use in lowering serum HC, CT, MMA, or 2-MCA in patients with or at risk for neuropsychiatric, vascular, renal or hematologic diseases. One embodiment of the invention is the use of a non-prescription formulation containing 2.0 mg B.sub.12 and 0.4 mg folic acid, with and without 25 mg B.sub.6. Another embodiment uses a prescription strength formulation containing 2.0 mg B.sub.12 and 1.0 mg folic acid, with and without 25 mg B.sub.6. The method of the present invention eliminate the costly and time consuming steps of distinguishing between vitamin deficiencies once a deficiency is found by measurement of serum metabolite levels. The present invention is of particular benefit to the populations at risk for elevated serum metabolite levels, such as the people over the age of 65, and populations that have or are at risk for neuropsychiatric, vascular, renal and hematologic diseases.

REFERENCES:
patent: 4940658 (1990-07-01), Allen et al.
patent: 4945083 (1990-07-01), Jansen, Jr.
patent: 5374560 (1994-12-01), Allen et al.
Gilman et al. "The Pharmacological Basis of Therapeutics", Published 1980 By MacMillan (pp. 1333-1340).
Barness, American Journ. of Clin. Nutr. (20) 1967 pp. 573-577.

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