Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Cyclopentanohydrophenanthrene ring system doai
Patent
1998-01-26
1999-07-27
Spivack, Phyllis G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Cyclopentanohydrophenanthrene ring system doai
514182, A61K 3157
Patent
active
059290617
ABSTRACT:
The present invention provides methods for treating migraine headache comprising administering an effective amount of a neurosteroid that directly or indirectly activates GABA.sub.A receptors.
REFERENCES:
patent: 5232917 (1993-08-01), Bolger et al.
Singh, I, et al. The Lancet;745-747 (May 31, 1947).
Shove, L.T., Bioorganic & Medicinal Chemistry, 2(10):1029-1049 (1994).
TenBrink, R.E., J. Med. Chem. 37:758-768 (1994).
Lee, C.M., et al., Neuroscience Letters, 127:237-241 (1991).
Bennett, D.A., et al., Drug Development Research, 4:75-82 (1984).
Martin, J.R., et al., Drug Development Research, 36:141-149 (1995).
Fryer, R.I., et al., Journal of Medicinal Chem., 36:1669-1673 (1993).
Hollinshead, S.P., et al., J. Med. Chem., 33:1062-1069 (1990).
Marder, M., et al., Biochemical and Biophysical Research Communication, 223:384-389 (1996).
Guerrini, G., et al., Eur. J. Med. Chem., 31:259-272 (1996).
Moskowitz, M., et al., Annu. Rev. Med., 44:145-154 (1993).
Serensen, K.V., Acta Neurol Scan., 78:346-348 (1988).
Haefely, J., et al., TIPS, 11:452-456 (1990).
Sieghart, W., TIPS, 13:446-450 (1992).
Guisti, L., et al., GABAergic Syaptic Transmission, 133-141 (1992).
Jussofie, A., Acto Endo, 129:480-485 (1993).
Beckham, J., et al., Headache, 32:292-297 (1992).
Moskowitz, M., Cerebrovascular and Brain Metabolism Reviews, 5:159-177 (1993).
Moskowitz, M., Trends in Pharm. Sciences, 13:307-311 (1992).
Hering, R., et al., Cephalalgia, 9:195-198 (1989).
Herring, et al., Cephalalgia, 12:81-84 (1992).
Mathew, N., Headache, 31:71-74 (1991).
Jones, M., et al., The Lancet, 1179-1181 (May 30, 1991).
Frye, C., et al., Brain Research, 643:194-203 (1994).
Sorensen, K.V., Acta Neurol. Scan., 78:346-348 (1988).
Hoke, J., et al., J. Clin. Pharmac., 33:458-462 (1993).
Browne, T.R., et al., Neurology, 37:184-189 (1987).
Ring, H.A., et al., Neurosurgery and Psych. 53:1051-1055 (1990).
Kalviainen, R., et al., Drugs, 46(6):1009-1024 (1993).
Snyder, S., JAMA, 261:3126-3129 (1989).
Lee et al., Brit. J. Pharmacol. "Peripheral GABA-A Receptor-Mediated Effects of Sodium Valproate on Dural Plasma Protein Extravasation to Substance P and Trigeminal Stimulation" 116:1 pp. 1661-1667; 1995.
Kelly et al., Prog. Migraine Res. "Cerebrovascular and Metabolic Influences of GABA in Relation to Migraine" 1, pp. 100-105 (1981).
Stensrud, P. and Sjaastad, O. Headache "Clonazepam (Rivotril) in Migraine Prophylaxis" 19:6, pp. 333-334 (1979).
Othmer, S.C. et al., J. Clin. Psychiatr. "Refractory Migraine Headache Controlled With Alprazolam: Case Report" 46:11 pp. 494-495 (1985).
Raskin, Neil H., Neurology "Repetitive Intravenous Dihydroergotamine as Therapy for Intractable Migraine" 36:7, pp. 995-997 (1986).
Dalton, K. et al., Headache "Progesterone Suppositories and Pessaries in the Treatment of Menstrual Migraine" 12:4 pp. 151-159 (1973).
Spivack Phyllis G.
The General Hospital Corporation
LandOfFree
Method for treating vascular headaches does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for treating vascular headaches, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for treating vascular headaches will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-878902