Method for treating type II diabetes employing a cholesterol low

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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A61K 3135

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active

051303337

ABSTRACT:
A method is provided for preventing or reducing the risk of or treating Type II diabetes by administering a cholesterol lowering drug, such as pravastatin, alone or in combination with an ACE inhibitor, such as captopril, zofenopril, ceranapril, fosinopril, enalapril or lisinopril.

REFERENCES:
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Garg and Grundy, "Lovastatin Therapy for Cholesterol Lowering in Non-Insulin Dependent Diabetes Mellitus (NIDDM)," Clin. Res. (35, No. 3, 503A, 1987).
Garg et al, "Lovastatin for lowering cholesterol levels in non-insulin-dependent diabetes mellitus," New England J. Med., Jan. 14, 1988, (2) p. 81-86.
Garg et al, "Treatment of dyslipidemia in non-insulin-dependent diabetes mellitus with lovastatin," Am. J. Cardiol. (U.S.) Nov. 11, 1988, (15) pp. 44J-49J.
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Pollare, T., et al, "A Comparison of the Effects of hydrochloroethiazide and Captopril on Glucose and Lipid Metabolism in Patients with Hypertension," New England Journal of Medicine, 321:868-873 (Sep. 28) 1989.
Rett, K. et al, "Role of angiotensin-converting enzyme inhibitors in early anti-hypertensive treatment in non-insulin dependent diabetes mellitus," Postgrad Med. J. 1989a/ 64 (Suppl. 3):69-73.
Rett, K. et al, "Angiotensin converting enzyme inhibitors in diabetes: experimental and human experience," Postgrad. Med. J. (U.K.), 1986 62/Suppl. 1 (59-64).
Jauch, K. et al, "Captopril enhances insulin responsiveness of forearm muscle tissue in non-insulin-dependent diabetes mellitus," Eur. J. Clin. Invest. (U.K.), 1987, 17/5 (448-454).

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