Method for treating tumors with cis-diammineplatinum(II) orthoph

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant virus encoding one or more heterologous proteins...

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424287, A61K 31685, A61K 3128

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active

042871875

ABSTRACT:
Cis-diammineplatinum(II) orthophosphate complexes are prepared by reaction of diaquo-cis-diammineplatinum(II) salts with alkali metal orthophosphates. The resulting complexes possess pronounced activity against tumors in mice combined with low animal toxicity.

REFERENCES:
patent: 4115418 (1978-09-01), Gale et al.
Rosenberg et al., Nature, vol. 222, 1969, pp. 385-386.
Cleare, Coordination Chemical Reviews, 12, (1974), pp. 349-405.
Cleare et al., Bioinorganic Chemistry, 2, 1973, pp. 187-210.
Gale et al., Cancer Treatment Reports, 61, 1977, pp. 1519-1525.

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