Method for treating tumors using cis-diammineplatinum (II) organ

Details Method for treating tumors using cis-diammineplatinum (II) organ Method for treating tumors using cis-diammineplatinum (II) organ

1979-12-26

1981-09-22

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated via claimed linking group, bond, chelating agent,...

424199, 424204, 424287, A61K 3170, A61K 31685, A61K 3166, A61K 3128

Patent

active

042910234

ABSTRACT:
Cis-diammineplatinum (II) organophosphate complexes where the organophosphate moiety is a glycerophosphate or a monosaccharide phosphate moiety are prepared by reaction of cis-diaquodiammineplatinum (II) salts with alkali metal organophosphates. The resulting complexes possess pronounced anti-tumor activity and low toxicity; consequently, they have high therapeutic indices.

REFERENCES:
patent: 3759896 (1973-09-01), Komatsu et al.
Cleare, Transition Metal Complexes in Cancer Chemotherapy", Coordination Chemistry Rev. 12, pp. 349-405, (1974).
Cleare et al., Bioinorganic Chemistry 2, pp. 187-210, (1973).
Gale et al., Cancer Treatment Reports 61, pp. 1519-1525, (1977).
Connors et al., Platinium Coordination Complexes in Chemotherapy, Springer-Verlag, N.Y., pp. 63-72, (1973).

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