Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1997-03-07
1999-11-30
Rotman, Alan L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546122, 435 72, A61K 31395, C07D47102
Patent
active
059943670
ABSTRACT:
The present invention provides compounds of Formula I: ##STR1## wherein A and R.sub.1 -R.sub.8 are defined herein. The compounds of Formula I inhibit the polymerization of tubulin and possess antimitotic activity. The compounds of Formula I may be useful for the treatment of psoriasis, gout, papiloma, warts, and a variety of tumors.
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Chen Ke
Kuo Sheng-Chu
Lee Kuo-Hsiung
Aulakh Charanjit S.
Rotman Alan L.
The University of North Carolina at Chapel Hill
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