Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof
Patent
1994-02-24
1996-01-30
Parr, Margaret
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Monoclonal antibody or fragment thereof
4241581, 53038825, 5303881, A61K 39395, C07K 1618
Patent
active
054878926
ABSTRACT:
Methods for the use of a fibrin-specific antibody for in vivo inhibition of thrombus formation. Pharmaceutical compositions, as well as kits, for use in such methods are also provided.
REFERENCES:
patent: 4722903 (1988-02-01), Kudryk et al.
patent: 4758524 (1988-07-01), Bundesen et al.
patent: 4916070 (1990-04-01), Matsueda et al.
patent: 5091512 (1992-02-01), Gargan et al.
patent: 5120834 (1992-06-01), Gargan et al.
patent: 5223410 (1993-06-01), Gargan et al.
Waldmann, T. A., Science, 252:1657-1662, Jun. 21, 1991.
Harris, W. J. et al., TibTech, 11:42-44, Feb. 1993.
Hui, K. Y. et al., Fibrinolysis, 4 (Supp. 3): 25, 1990.
Gargan, P. E. et al., Fed. Am. Soc. Exp. Biol, J5 (4): A464, 1991 (Apr. 21-25).
Rosebrough, S. F. et al., J. Nucl. Med., 31(6):1048-1054, 1990.
Bang and Chang, 1974, "Soluble fibrin complexes", in: Semin Thromb Hemost 1(2):91-128.
Cierniewski and Budzynski, 1992, "Involvement of the .alpha.chain in fibrin clot formation. Effect of monoclonal antibodies", Biochemistry 31(17):4248-4253.
Francis et al., 1985, "Some studies with a monoclonal antibody directed against human fibrinogen", Am J Hematol 18:111-119.
Gargan et al., 1993, "A monoclonal antibody which recognizes an epitopic region unique to the intact fibrin polymeric structure", Fibrinolysis 7(4):275-283.
Gargan et al., 1988, "A fibrin specific monoclonal antibody which interferes with the fibrinolytic effect of tissue plasminogen activator", Thrombosis and Haemostasis 59(3):426-431.
Gimple et al., 1992, "Effect of chronic subcutaneous or intramural administration of heparin on femoral artery restenosis after balloon angioplasty in hypercholesterolemic rabbits", Circulation 86(5):1536-1546.
Hoots et al., 1981, "A naturally occurring antibody that inhibits fibrin polymerization", New Engl J Med 304(15):857-861.
Ip et al., 1991, "The role of platelets, thrombin, and hyperplasia in restenosis after coronary angioplasty", J Am Coll Cardiol 17(6):77B-88B.
Knight et al., 1988, "Evaluation of Indium-111-labeled anti-fibrin antibody for imaging vascular thrombi", J Nucl Med 29:494-502.
Kudryk et al., 1991, "Fibrinogen-fibrin: Preparation and use of monoclonal antibodies as diagnostics", Biotechnology 19:281-313.
Liau et al., 1987, "Evaluation of monoclonal antifibrin antibodies by their binding to human blood clots", Thrombosis and Haemostatis 57(1):49-54.
Lill et al., 1993, "A new immunoassay for soluble fibrin enables a more sensitive detection of the activation state of blood coagulation in vivo", Blood Coagulation and Fibrinolysis 4:97-102.
Marciniak and Greenwood, 1979, "Acquired coagulation inhibitor delaying fibrinopeptide release", Blood 53(1):81-92.
Matsueda and Margolies, 1986, "Structural basis for the species selectivity of a fibrin-specific monoclonal antibody", Biochemistry 25:1451-1455.
Mirshahi et al., 1990, "A monoclonal antibody to fibrinogen inhibiting fibrin polymerization", Fibrinogen 4. Current Basic And Clinical Aspects: Proceedings of the Intl Fibrinogen Workshop, Kyoto, Japan, pp. 49-54.
Muller-Berghaus et al., 1985, "Detection of fibrin in plasma by a monoclonal antibody against the amino-terminus of the alpha-chain of fibrin", Scand J Clin Lab Invest 45(Suppl 178):145-151.
Nieuwenhuizen, 1993, "Soluble fibrin as a molecular marker for a pre-thrombotic state: A mini-review", Blood Coagulation and Fibrinolysis 4:93-96.
Nieuwenhuizen et al., 1992, "A rapid monoclonal antibody-based enzyme immunoassay (EIA) for the quantitative determination of soluble fibrin in plasma", Thrombosis and Haemostasis 68(3):273-277.
Scheefers-Borchel et al., 1985, "Discrimination between fibrin and fibrinogen by a monoclonal antibody against a synthetic peptide", Proc Natl Acad Sci USA 82:7091-7095.
Selmayr et al., 1985, "Crosslinking of soluble fibrin and fibrinogen", Thrombosis Research 39:467-474.
Selmayr and Muller-Berghaus, 1985, "Soluble-crosslinked fibrin(ogen) polymers", Thrombosis and Haemostasis 54(4):804-807.
Sobel et al., 1988, "Early alpha chain crosslinking in human fibrin preparations", Thrombosis and Haemostasis 60(2):153-159.
Sola et al., 1983, "Isolation and characterization of a monoclonal antibody specific for fibrinogen and fibrin of human origin", Thrombosis Research 29:643-653.
Tymkewycz et al., 1993, "Generation and partial characterization of five monoclonal antibodies with high affinities for fibrin", Blood Coagulation and Fibrinolysis 4:211-221.
Wasser et al., 1990, "Thrombus detection using Tc-99m labeled antifibrin monoclonal antibody (MoAb) experiments in vitro and in animals", Thrombosis Research Supplement X:91-104.
American Biogenetic Sciences Inc.
Loring Susan A.
Parr Margaret
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