Method for treating thromboembolic conditions via the use of mul

Details Method for treating thromboembolic conditions via the use of mul Method for treating thromboembolic conditions via the use of mul

1994-03-25

1997-11-25

Jacobson, Dian C.

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

424 9463, 435212, 435226, A61K 3848, A61K 3849, C12N 964, C12N 1555

Patent

active

056909314

ABSTRACT:
Discussed are therapeutic approaches to the treatment of thrombolic conditions. The therapies use thrombolytically active proteins which function by, e.g., inhibiting reocclusion in the subject. The proteins are administered in two or more boli.

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Khan et al., "Effectiveness of Multiple Bolus Administration of Tissue-Type Plasminogen Activator in Acute Myocardiol Infarction", Am. J. Cardiol. 65(16): 1051-1056 (1990).
Gemmill et al., "High Coronary Artery Patency and Plasma Recombinant Tissue Plasminogen Activator Concentrations After Bolus Administration of Alteplase in Acute Myocardiol Infarction", Br. Heart Journal 64(1): 52 (1990).
Martin et al., "Properties of a Novel Plasminogen Activator (BM 06.022) produced in Escherichia coli", Z Kardiol 79: Suppl. 3, 167-170 (1990).

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