Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1996-05-13
1999-03-30
Rose, Shep K.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
514771, 514891, 536 551, 5361231, A61K 31725
Patent
active
058889868
ABSTRACT:
A method of treating interstitial cystitis comprising contacting the transitional epithelium lining the urinary bladder and associated structures in a mammal having interstitial cystitis with a solution containing hyaluronic acid having a average molecular weight of not less than 2.times.10.sup.5 Daltons in a concentration effective to treat the interstitial cystitis.
REFERENCES:
patent: 4141973 (1979-02-01), Balazs
patent: 4296104 (1981-10-01), Herschler
patent: 4302577 (1981-11-01), Rucker
patent: 4524066 (1985-06-01), Wolf
patent: 4640912 (1987-02-01), Hausman
patent: 4711780 (1987-12-01), Fahim
patent: 4820693 (1989-04-01), Gillespie
patent: 4879282 (1989-11-01), Saliba, Jr.
patent: 4966890 (1990-10-01), Gillespie
patent: 5037810 (1991-08-01), Saliba, Jr.
patent: 5180715 (1993-01-01), Parsons
Stewart et al., "The Use of Dimethyl Sulfoxide (DMSO) in the Treatment of Interstitial Cystitis," J. Urology, vol. 98, pp. 671-672 (1968).
Parsons et al., "Decreased Urinary Uronic Acid Levels in Individals with Interstitial Cystitis," J. Urology, vol. 143, pp. 690-693 (1990).
Fleischmann et al., "Clinical and Immunological Response to Nifedipine for the Treatment of Interstitial Cystitis," J. Urology, vol. 146, pp. 1235-1239 (1991).
Nickel et al., "The Bladder Mucus (Glycosaminoglycan) Layer in Interstitial Cystitis," J. Urology, vol. 149, pp. 716-718 (1993).
Hanno et al., "Conservative Therapy of Interstitial Cystitial," Seminars in Urology, vol. 9, No. 2, pp. 143-147 (1991).
Chelsky et al., "Bladder Permeability in Interstitial Cystitis is Similar to that of Normal Volunteers: Direct Measurement by Transvesical Absorption of 99mTechnetiumdiethylenetriaminepentaacetic Acid," J. Urology, vol. 151, pp. 346-349 (1994).
Eldrup et al., "Permeability and Ultrastructure of Human Bladder Epithelium," Br. J. Urology, vol. 55, pp. 488-492 (1983).
Brandt, "The Effect of Synovial Hyaluronate on the Injestion of Monosodium Urate Crystals by Leukocytes," Clinica Chimica Acta, vol. 55, pp. 307-315 (1974).
Messing et al., "Interstitial Cystitis," Urology, vol. 12, No. 4, pp. 381-392 (1978).
Balazs et al., "The Effect of Hyaluronic Acid on Fibroblasts, Mononuclear Phagocytes and Lyphocytes," Biology of Fibroblasts, Academic Press, pp. 237-252 (1973).
Kuwahara et al., "Bacterial Infection and Acid Mucopolysaccharides in Epithelium of Rat Urinary Bladder," Urological Research, vol. 10, No. 2, pp. 93-96 (1982).
Gill et al., "Protective Effects of Heparin and Other Sulfated Glycosaminoglycans on Crystal Adhesion to Injured Urothelium," J. Urology, vol. 127(1), pp. 152-154 (1982).
Maroudas, N.G. et al., "Polymer Treatments Reduce Adhesion of Comminuted Store in Rat Bladder," British Journal of Urology, vol. 59(6), pp. 519-522 (1987).
Laurent, C. et al., "Localization and Quantity of Hyaluronan in Urogenital Organs of Male and Female Rats," Cell & Tissue Research, vol. 279(2), pp. 241-248 (1995).
Holm-Bentzen, Merete et al., "Glycosaminoglycans on the Surface of the Human Urothelium: A Preliminary Report," Neurology and Urodynamics, vol. 5(6), pp. 519-523 (1986).
Wakatsuki, Akira et al., "Possible Role of Hyaluronate in Experimental Renal Stone Formation in Rabbits," Journal of Urology, vol. 133(2), pp. 319-323 (1985).
Hurst, Robert E. et al., "Functional and Structural Characteristics of the Glycosaminoglycans of the Bladder Luminal Surface," J. Urology, vol. 138(2), pp. 433-437 (1987).
The Merck Index, 11th Ed., p. 7093 at 7090 (1989).
Strohmaier, W.L., "Therapie Der Interstitiellen Bzm. Radiogenen Zystitis Mit D-Glukosamin," Hel. Chir. Acta, vol. 56, pp. 323-325 (1989).
Kiesewetter, E. et al., "Einflub der Hyaluronsaure auf eine schwere Harnwegsinfektion bei idiopathischer Hyperkalzurie," Z.Urologie und Nephrologie, vol. 58(10), pp. 735-738 (1965).
Perez-Marrero, R., et al., "A Controlled Study of Dimethyl Sulfoxide in Interstitial Cystitis," Journal of Urology, vol. 140, pp. 36-39 (1988).
Wein, A.J., et al., "Interstitial Cystitis; Current and Future Approaches to Diagnosis and Treatment," Urologic Clinics of North America, vol. 21, No. 1, pp. 153-161 (1994).
Alkemade Stanley J.
Morales Alvaro
Bioniche Inc.
Rose Shep K.
LandOfFree
Method for treating the urinary bladder and associated structure does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for treating the urinary bladder and associated structure, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for treating the urinary bladder and associated structure will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1215145