Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1994-04-07
1996-02-20
Robinson, Douglas W.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
514 46, 514908, A61K 3170
Patent
active
054928974
ABSTRACT:
6-Alkoxy derivatives of Ara-G, and pharmaceutically acceptable esters thereof, are described as being useful in tumor therapy. Novel pharmaceutically acceptable esters, their preparation and pharmaceutical formulations containing them are also disclosed.
REFERENCES:
patent: 3872084 (1975-03-01), Jones et al.
Donna S. Schewach, et al.; Metabolism and Selective Cyctotoxicity of 9-D-Arabinofuranosyljuanine in Hyman Lymphoblasts; Cancer Research, vol. 45; Mar. 1985; pp. 1008-1014.
Buddy Ullman, et al.; Specific Cytotoxicity of Arabinosylguanine Toward Cultured T. Lymphoblasts; vol. 74; Sep. 1984; pp. 951-955.
Andrew M. Yeager et al.; Autologous Bone Marrow Transplantation In Patients With Acute Nonlymphocytic Leukemia, Using Ex Vivo Marrow Treatment With 4-Hydroperoxycyclophosphamide; vol. 315; Jul. 17, 1986, No. 3; pp. 142-147.
G. W. Santos; The Johns Hopkins Onconology Center; Busulfan (BU) and Cyclophosphamide (CY) for Marrow Transplantation; Bone Marrow Transplant, Jan. 1989; 4 suppl. 236-9.
Cohen, et al., Selective Toxicity of Deoxyguanosine and Arabinosyl Guanine for T-Leukiemic Cells, Blood, vol. 61, No. 4, Apr. 1983, pp. 660-666.
The Journal of Clinical Investigation. vol. 74, No. 3, Sep., 1984.
European Search Report.
Averett Devron R.
Koszalka George W.
Krenitsky Thomas A.
Wolberg Gerald
Brown Donald
Burroughs Wellcome Co. (141)
Green Hannah O.
Robinson Douglas W.
Wilson James O.
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