Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Hydrolases
Patent
1991-12-31
1995-03-07
Robinson, Douglas W.
Drug, bio-affecting and body treating compositions
Enzyme or coenzyme containing
Hydrolases
A61K 3754
Patent
active
053956125
ABSTRACT:
Reducing plasma levels of endogenous arginine by parenteral administration of arginine depleting agent limits nitric oxide formation and results in blood pressure increase. Preferably arginase is administered intravenously to raise blood pressure. The arginine depleting agent can be administered in conjunction with arginine antagonists to potentiate the effect of these. The arginine depleting agent can be used concurrently with .alpha..sub.1 adrenergic agonists in treating systemic hypotension caused by induced production of nitric oxide, to restore vascular contractile sensitivity to the effect of the .alpha..sub.1 adrenergic agonists. Duration of action and avoidance of antigenicity may be obtained by use in conjunction with a carrier or modifier.
REFERENCES:
patent: 2663668 (1953-12-01), Vrat
patent: 2834713 (1958-05-01), Robbins
patent: 4282217 (1981-08-01), Baglioni et al.
patent: 4734438 (1988-03-01), Macri
patent: 5028627 (1991-07-01), Kilbourn et al.
patent: 5059712 (1991-10-01), Griffith
patent: 5196195 (1993-03-01), Griffith
patent: 5216025 (1993-06-01), Gross et al.
patent: 5286739 (1994-02-01), Kilbourn et al.
Ramanathan S et al, Acta Anaesthesiol Scand. 32:559-65 (1988).
Thermermann C et al, Eur. J. Pharmacol 182:591-5 (1990).
Aisaka, K., Biochemical and Biophysical Research Communications, 163, No. 2, 710-717 (Sep. 1989).
Hibbs, J. B., et al, The Journal of Immunology, 138, No. 2, 550-565 (1987).
Jackson, J. A., et al, J. Pharmacol. Expt. Ther. 209, 271-274 (1979).
Ko, R. Y. C., et al, J. Biomed. Res. 10, 249-258 (1976).
Olanoff, L. S., et al, J. Biomed. Res. 8, 125-136 (1977).
Savoka, K. V., et al, Biochem. Biophys. Acta 578, 47-53 (1979).
Blethen, S. L., et al, J. Biol. Chem., vol. 243, No. 8, 1671-1677 (1968).
Mitchell, J. A., et al, European Journal of Pharmacology, 182, 573-576 (1990).
Olken, N. M., et al, Biochem. Biophys. Res. Comm., vol. 177, No. 2, 828-833 (Jun. 14, 1991).
Stuehr, D. J., et al, Proc. Natl. Acad. Sci. USA, vol. 88, 7773-7777 (Sep. 1991).
Taylor, H., et al (ed.), Methods in Enzymology, vol. XVIIA, pp. 310-317, 335-340, Academic Press, 1970.
Yui, Y., et al, J. Biol. Chem., vol. 266, No. 19, 12544-12547, 1991.
Stuehr, D. J. et al, Synthesis of Nitrogen Oxides from L-Arginine by Macrophage Cytosol: Requirement for Inducible and Constitutive Components, Biochem, Biophys. Res. Commun., (1989) vol. 161, 420-426.
Stuehr, D. J. et al., Activated Murine Macrophages Secrete a Metabolite of Arginine with the Bioactivity of Endothelium-Derived Relaxing Factor and the Chemical Reactivity of Nitric Oxide, J. Exp. Med., (1989) vol. 169, 1011-1020.
Rees, D. D. et al., Role of Endothelium-Derived Nitric Oxide in the Regulation of Blood Pressure, Proc. Natl. Acad. Sci. U.S.A., (1989) vol. 86, 3375-3378.
Aisaka, K. et al., N.sup.G -Methylarginine, An Inhibitor of Endothelium-Derived Nitric Oxide Synthesis, is a Potent Pressor Agent in the Guinea Pig: Does Nitric Oxide Regulate Blood Pressure in vivo, Biochem. Biophys. Res. Commun. (1989), 160:881-886.
Natanson, C. et al., Endotoxin and Tumor Necrosis Factor Challenges in Dogs Simulate the Cardiovascular Profile of Human Septic Shock, Journal of Exp. Med. (1989) 169:823-832.
Schmidt, H. et al., Arginine is a Physiological Precursor of Endothelium-Derived Nitric Oxide, Eur. J. of Pharmacology (1988) 154:213-216.
Palmer, R. M. J. et al., L-Arginine is the Physiological Precursor for the Formation of Nitric Oxide in Endothelium-Dependent Relaxation, Biochem. Biophys. Res. Commun. (1988) 153:1251-1256.
Sakuma, I. et al., Identification of Arginine as a Precursor of Endothelium-Derived Relaxing Factor, Proc. Natl. Acad. Sci U.S.A. (1988) 85:8664-8667.
Palmer, R. M. J. et al., Vascular Endothelial Cells Synthesize Nitric Oxide from Arginine, Nature, (1988) vol. 333, 664-666.
Hibbs, J. B. et al., Nitric Oxide: A Cytotoxic Activated Macrophage Effector Molecule, Biochem. Biophys. Res. Commun. (1988) 157:87-94.
Marletta, M. A. et al., Macrophage Oxidation of L-Arginine to Nitrite and Nitrate: Nitric Oxide Is an Intermediate, Biochemistry (1988) 27:8706-8711.
Palmer, R. M. J. et al., Nitric Oxide Release Accounts for the Biological Activity of Endothelium-Derived Relaxing Factor, Nature (1987) 327:524-526.
Stuehr, D. J. et al., Induction of Nitrite/Nitrate Synthesis in Murine Macrophages by BCG Infection, Lymphokines, or Interferon-.gamma., J. of Immunology (1987) 139:518-525.
Iyengar, R. et al., Macrophage Synthesis of Nitrite, Nitrate and N-Nitrosamines: Precursors and Role of the Respiratory Burst, Proc. Natl Acad. Sci. U.S.A. (1987) vol. 84, 6369-6373.
Turan, et al., Acta Chimica Academiae Scientiarum Hungaricae (1975) 85:327-332.
Kilbourn et al., N.sup.G -Methyl-L-Arginine Inhibits Tumor Necrosis Factor-Induced Hypotension: Implications for the Involvement of Nitric Oxide Proc. Natl. Sci. U.S.A. (1990) 87:3629-3632.
Gray, G. A., et al, Br. J. Pharmacol., 103, 1218-1224 (1991).
Julou-Schaeffer, G., et al, Am. J. Physiol. 259, H1038-H1043, (1990).
Billar, T. R., Journal of Leukocyte Biology 48:565-569 (1990).
Moncada, S., et al, Pharmacological Reviews 43(2):109-142 (1991).
Griffith, O. W., et al, The Role of Plasma Arginine in Nitric Oxide Synthesis: Studies with Arginase-Treated Rats, from the Book of Abstracts, Second International Meeting "Biology of Nitric Oxide", handed out Sep. 29, 1991.
Griffith Owen W.
Gross Steven S.
Levi Roberto
Cornell Research Foundation Inc.
Robinson Douglas W.
Saucier Sandra
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