Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1994-02-14
1997-01-14
Weddington, Kevin E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514327, 514408, 514731, A61K 31445, A61K 3140, A61K 3105
Patent
active
055940072
ABSTRACT:
A method of blocking N-methyl-D-aspartic acid (NMDA) receptor sites in a mammal in need thereof with an effective NMDA blocking (neuroprotective and antiischemic) amount of prodrug esters of 2-piperidino-1-alkanol derivatives and prodrug esters of 2-azabicyclo-1-alkanol derivatives and analogs and pharmaceutically acceptable salts thereof; methods of using these compounds in the treatment of stroke, spinal cord trauma, traumatic brain injury, multiinfarct dementia, CNS degenerative diseases such as Alzheimer's disease, senile dementia of the Alzheimer's type, Huntington's disease, Parkinson's disease, epilepsy, amyotrophic lateral sclerosis, pain, AIDS dementia, psychotic conditions, drug addictions, migraine, hypoglycemia, anxiolytic conditions, urinary incontinence and an ischemic event arising from CNS surgery, open heart surgery or any procedure during which the function of the cardiovascular system is compromised.
REFERENCES:
patent: 4902695 (1990-02-01), Ornstein
patent: 4968678 (1990-11-01), Ornstein
patent: 5163313 (1992-11-01), Haas, Jr. et al.
patent: 5185343 (1993-02-01), Chenard
patent: 5192751 (1993-03-01), Thor
patent: 5272160 (1993-12-01), Chenard
patent: 5338754 (1994-08-01), Chenard
patent: 5352683 (1994-10-01), Mayer et al.
patent: 5455250 (1995-10-01), Chenard
Schoepp et al., J. Neur. Trans., 85, 131-43 (1991).
Lehman, Drugs of the Future, 14(11), 1059 (1989).
McLachlan, Canadian Journal of Neurological Science, 19(4), 487 (1992).
Trujillo and Akil, Science, 251, 85 (1991).
Lehman et al., PIPS, 11, 1 (1990).
Bundagard et al., J. Med. Chem., 32, 2503-07 (1989).
Hansen and Krogsgaard-Larson, Med. Res. Rev., 10, 55-94 (1990).
Murphy et al., British J. Pharmacology, 95, 932-38 (1988).
Harrison and Simmonds, British J. Pharmacology, 84, 381-91 (1984).
Benson Gregg C.
Pfizer Inc.
Richardson Peter C.
Ronau Robert T.
Weddington Kevin E.
LandOfFree
Method for treating spinal cord trauma with phenolic 2-piperidin does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for treating spinal cord trauma with phenolic 2-piperidin, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for treating spinal cord trauma with phenolic 2-piperidin will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1388496