Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1995-01-31
1996-11-05
Criares, Theodore J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514315, 514317, 514319, 514324, 514422, 514578, 514333, A61K 3155, A61K 31445, A61K 3140, A61K 31185
Patent
active
055718086
ABSTRACT:
A method for treating smoking-related bone loss comprising administering to a human in need thereof a pharmaceutically-effective amount of a compound having the formula ##STR1## wherein R.sup.1 and R.sup.3 are independently hydrogen, C.sub.1 -C.sub.4 alkyl, --CO--(C.sub.1 -C.sub.6 alkyl), or --CH.sub.2 Ar, --CO--Ar, wherein Ar is phenyl or substituted phenyl;
REFERENCES:
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Jordan et al., "Effects of anti-estrogens on bone in castrated and intact female rats," Breast Cancer Research and Treatment, 10, 31-35 (1987).
Slemenda, "Cigarettes and the Skeleton," N. Engl. J. Med., 330, 430-431 (1994).
Hopper and Seeman, "The Bone Density of Female Twins Discordant for Tobacco Use," N. Engl. J. Med., 330, 387-392 (1994).
Jensen et al., "Cigarette Smoking, Serum Estrogens, and Bone Loss During Hormone-Replacement Therapy Early After Menopause," N. Engl., J. Med., 313, 973-975 (1985).
Kiel et al., "Smoking Eliminates the Protective Effect of Oral Estrogens on the Risk for Hip Fracture Among Women," Ann. Intern. Med., 116, 716-721 (1992).
Boone David E.
Criares Theodore J.
Eli Lilly and Company
Leeds James P.
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