Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2001-06-28
2009-02-03
Padmanabhan, Sreeni (Department: 1617)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S921000
Reexamination Certificate
active
07485642
ABSTRACT:
Levosimendan, or (−)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]hydrazono]propanedinitrile, which has been mentioned for the treatment of congestive heart failure, is useful in the treatment of septic shock.
REFERENCES:
patent: 0565546 (1993-10-01), None
patent: WO 93/21921 (1993-11-01), None
patent: WO 99/66912 (1999-12-01), None
patent: WO 01/00211 (2001-01-01), None
Spitzer et al. Prog Clin Biol Res. 1987; 236A, pp.573-590.
Paul S. Pagel et al., “Influence of Levosemendan, Pimobendan, and Milrinone on the Regional Distribution of Cardiac Output in Anaesthetized Dogs.”, British Journal of Pharmacology, vol. 119, pp. 609-615, 1996.
Ferenc Folláth et al., “Dose-Ranging and Safety with Intravenous Levosimendan in Low-Output Heart Failure: Experience in Three Pilot Studies and Outline of the Levosimendan Infusion Versus Dobutamine (LIDO) Trial.”, Am J Cardiol, vol. 83, pp. 21-25, 1999.
Athur P. Wheeler et al., “Treating Patients with Severe Sepsis”, The New England Journal of Medicine, vol. 340, pp. 207-214, Jan. 1999.
Matejovic et al., “Successful reversal of resistent hypodynamic septic shock with levosimendan,” Acta Anaesthesiol. Scand. 49:127 (2005).
Powell B. P. et al. “Levosimendan in septic shock: a case series,”Br. J. Anaesthesia(2007) 99(3):447.
Press Release: “Abbott Reports Improved Clinical Course with Levosimendan (Simdax®) When Added to Standard Therapy in Acute Decompensated Heart Failure Trial” (2007).
Oldner Anders
Rudehill Anders
Wanecek Michael
Weitzberg Eddie
Finnegan Henderson Farabow Garrett & Dunner LLP
Kantamneni Shobha
Orion Corporation
Padmanabhan Sreeni
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