Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Patent
1998-02-02
2000-01-04
Krass, Frederick
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
518563, 518564, 518566, 518567, 518616, 518626, 518629, 518649, 518653, 518654, 518663, 518673, 514674, A61K 3152, A61K 31195
Patent
active
06011066&
ABSTRACT:
A method for the treating septic shock in a patient comprises administering to the patient a therapeutically-effective amount of a composition comprising a compound having the formula (I): ##STR1## wherein R.sub.1 is hydrogen, hydroxyl, carboxyl, amino or C.sub.1 -C.sub.8 alkyl; R.sub.2 is hydrogen, hydroxyl, amino or C.sub.1 -C.sub.8 alkyl; and R.sub.3 is hydrogen, hydroxyl, carboxyl, amino, C.sub.1 -C.sub.8 alkyl, substituted or unsubstituted phenyl, amide, C.sub.3 -C.sub.8 aminoalkyl, or C.sub.1 -C.sub.8 aminoalkylcarbonyl; or a therapeutically-effective salt, ester or solvate thereof. Particularly preferred compounds for use in the present invention include butylamine, propylamine, diaminopropane, diaminobutanone, tyrosine, threonine, asparagine, and aspartate.
REFERENCES:
patent: 4388318 (1983-06-01), Koyama et al.
patent: 4822776 (1989-04-01), Cerami et al.
patent: 5028627 (1991-07-01), Kilbourn et al.
patent: 5068314 (1991-11-01), Nakamura et al.
patent: 5162571 (1992-11-01), Shiraishi et al.
patent: 5171739 (1992-12-01), Scott
patent: 5175183 (1992-12-01), Brooks et al.
patent: 5286739 (1994-02-01), Kilbourn et al.
patent: 5306710 (1994-04-01), Wei
patent: 5334380 (1994-08-01), Kilbourn et al.
patent: 5374651 (1994-12-01), Kibourn et al.
patent: 5436270 (1995-07-01), Wang
patent: 5502055 (1996-03-01), Wang
patent: 5530113 (1996-06-01), Christ et al.
patent: 5534545 (1996-07-01), Kilbourn et al.
patent: 5576350 (1996-11-01), Wang
patent: 5594113 (1997-01-01), Wainwright et al.
patent: 5656608 (1997-08-01), Schneider et al.
Souba, W.W., et al., "The role of glutamine in maintaining a healthy gut and supporting the metabolic response to injury and infection", J. Surg. Res. 1990 Apr.; 48(4):383-391.
Ardawi, M.S., "Effect of glutamine-enriched total parenteral nutrition on septic rats", Clin. Sci. (Colch) 81 (2): 215-222 (Aug. 1991).
Clowes, et al. "Effects of parenteral alimentation on amino acid metabolism in septic patients", Surgery, vol. 88, No. 4, pp. 531-543, Oct. 1980.
Krass Frederick
Veterans General Hospital-Taipei
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