Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1989-02-17
1991-05-28
Friedman, Stanley J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514648, A61K 3134, A61K 31135
Patent
active
050195913
ABSTRACT:
A method for treating and preventing retinopathy and for treating and preventing other small vessel complications associated with diabetes which comprises administering a therapeutically effective amount of an antihistamine or a pharmaceutically acceptable derivative thereof to a mammal having retinopathy or other small vessel complications associated with diabetes.
REFERENCES:
Chem. Abst, 103:171798r (1985); Akihiro et al.
Dull et al. Fed. Proc. 45,462 (1986).
Hollis, Exp. Mol. Pathol., 431 90-6 (1985).
Cunha Vaz, J. G., Faria de Abreu, J. R.; Campos, A. J., Figo, G. M.; "Early Breakdown of the Blood Retinal Barrier in Diabetes," Br. J. Ophthalmol., 59, 649-56 (1975).
Waltman, S. R., Oestrich, C., Krupin, T., Hanish, S., Ratzan, S., Santiago, J.; Kilo, C., "Quantitative Vitreous Fluorophotometry, A Sensitive Technique for Measuring Early Breakdown of the Bloodretinal Barrier in Young Diabetic Patients," Diabetes, 27, 85-7 (1970).
Ishibashi, T., Tanaka, K., Taniguchi, Y., "Disruption of Blood-Retinal Barrier in Experimental Diabetic Rats: An Electron Microscopic Study,"Exp. Eye. Res, 30, 401-10 (1980).
Orlidge, A., Hollis, T. M., "Aortic Endothelial and Smooth Muscle Histamine Metabolism in Experimental Diabetes," Arteriosclerosis, 2, 142-50 (1982).
Hollis, T. M., Kern, J. A., Enea, N. A.; Cosgarea, A. J., "Changes in Plasma Histamine Concentration in the Streptozotocin Diabetic Rat," Exp. Mol. Pathol, 43, 90-6 (1985).
Hollis, T. M. Gallik, S. G., Orlidge, A., Yost, J. C.; "Aortic Endothelial and Smooth Muscle Histamine Metabolism, Relationship to Aortic 125I Albumin Accumulation in Experimental Diabetes,"Arteriosclerosis, 3; 599-606 (1983).
Ryan, T. A., Joiner, B. L., Ryan, B. F.; Minitab Student Handbook, First Edition, (1976).
Carroll, W. C., Hollis, T. M., "Retinal Histamine Synthesis is Increased in Experimental Diabetes", Invest Ophthalmol., Vis. Sci, 29, 1201-04 (1988).
Dull, R. O. , Vergis, G. J., Hollis, T. M., "Effect of Chronic Histamine Infusion on the Permeability of the Blood Retinal Barrier,"Fed. Proc. 45, 462 (1986).
Katora, M. E., Hollis, T. M., "A Simple Fluorometric Method for Quantitative Determination of Aortic Protein Uptake,"J. Appl. Physiol. 39, 145-9 (1975).
Gardner Thomas W.
Hollis Theodore M.
Fay Zohreh A.
Friedman Stanley J.
Pennsylvania Research Corporation
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