Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1990-12-21
1992-04-21
Schain, Howard E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 12, A61K 3726
Patent
active
051068320
ABSTRACT:
Insulin-like growth factor I (IGF I) and pharmaceutical compositions comprising IGF I are useful in improving glomerular filtration and renal plasma flow and can be used for the treatment of patients suffering from renal diseases and for the preparation of therapeutic combinations for treatment of renal diseases.
REFERENCES:
Hirschberg et al., Kidney International, vol. 32, Suppl. 22 (1987) pp. S21-S24.
Guler et al., New England J. of Med., vol. 317, No. 3 (1987) pp. 137-140.
Scheiwiller et al., Nature, vol. 323, Sep. 11, 1986, pp. 169-171.
Guler, in Modern Concepts of Insulin-Like Growth Factors (Spencer, ed., Elsevier 1991), pp. 583-590.
Guler et al., PNAS:U.S.A., 85:4889-4893 (1988).
Guler et al., Acta Endocrinologica, 121:101-106 (1989).
Hirschberg et al., Kidney International, 35:865-870 (1989).
Schoenle et al., Acta Endocrinologica, 108:167-174 (1985).
Zapf et al., J. Clin. Invest., 68:1321-1330 (1981).
Guler et al., PNAS:U.S.A., 86:2868-2872 (1989).
Froesch Ernst R.
Guler Hans-Peter
Schmid Christoph
Zapf Jurgen
Ciba-Geigy Corporation
Fishman Irving M.
Koh Choon
Lazar Steven R.
Schain Howard E.
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