Method for treating psoriasis with cytotoxic agents

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514863, A61K 31505

Patent

active

048533882

ABSTRACT:
A method for treating psoriasis comprising applying an effective amount of a cytotoxic drug dispersed in a pharmaceutically acceptable vehicle containing a penetrating solvent for the drug, the drug being applied to the skin area affected by the psoriasis without occlusion in pulses of from 1 to 3 applications per pulse, the pulses being applied at an interval of once every from 3 to 30 days and preferably at an interval of from 4 to 14 days. Optimally, the penetrating solvent is free from toxic effects, such as AZONE or similar substituted azacycloalkyl-2-ones, tertiary amine oxides, and the like.

REFERENCES:
patent: 3989816 (1976-11-01), Rajadhyaksha
patent: 4423040 (1983-12-01), Rajadhyaksha
patent: 4636509 (1987-01-01), Phillipps et al.
patent: 4705791 (1987-11-01), Bemeche et al.
Pearlman et al., J. Am. Acad. Dormatol. vol. 17, No. 1, pp 78-82 (1987).
Pearlman et al. J. Am. Acad. Dermotol. 15:1247-52, 1986.
Peck et al., "Topical Lomustine in the Treatment of Psoriasis." Arch. Derm. 106:172-176 (1972).

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