Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant or stably-transformed bacterium encoding one or...
Patent
1977-05-02
1980-02-26
Ore, Dale R.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Recombinant or stably-transformed bacterium encoding one or...
424 14, 424239, 424315, 424317, 424318, 424361, 424362, A61K 31215, A61K 31185
Patent
active
041906691
ABSTRACT:
A process for the treatment of psoriasis comprising administering to humans or domesticated animals topically and/or systemically a composition comprising a pharmaceutical carrier and eicosa-5,8,11,14-tetraynoic acid, its congeners, and the lower alkyl esters thereof; in one preferred form of the invention the composition comprises a pharmaceutical carrier and 5,8,11 eicosatriynoic acid; in another preferred form of the invention the composition comprises a pharmaceutical carrier and at least one active compound selected from the groups eicosa-5,8,11,14-tetraynoic acid, its congeners and the lower alkyl esters thereof and at least one compound selected from the group consisting of PGE.sub.1, PGE.sub.2, PGE.sub.3 and the alkyl esters thereof containing from 1 to 8 carbon atoms inclusive, and 13,14-dihydro PGE.sub.1 and the alkyl esters thereof containing from 1 to 8 carbon atoms inclusive.
REFERENCES:
patent: 3033884 (1962-05-01), Osbond et al.
patent: 3450821 (1969-06-01), Cartensen et al.
patent: 3903297 (1975-09-01), Robert
Solomon et al., The Journal of Investigative Dermatology, 1968, vol. 51, No. 4.
Strauss et al., Chem. Abs., 1967, vol. 67, p. 2042x.
Hamberg Mats A.
Hammarstrom Sven R.
Samuelsson Bengt I.
Voorhees John J.
Ore Dale R.
The Regents of the University of Michigan
Waldrop Neal A.
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