Method for treating pre-malignant basal and squamous cell...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...

Reexamination Certificate

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C514S783000, C424S195110

Reexamination Certificate

active

06235788

ABSTRACT:

BACKGROUND OF THE INVENTION
The botanical substance Capsaicin, a derivative of Cayenne pepper and of other types of peppers, chilies and the like grow, in different areas of the world. As such, Capsaicin is a naturally occurring substance derived from plants of the Solanaceae family, and having a chemical name of trans 8, methyl-N-vanillyl 6-nonemamide. The same, in a chemical notation, corresponding to C
18
H
27
NO
3
. Capsaicin is a white crystalline power having a molecular weight of 305.4. It is substantially insoluble in water, however. is highly soluble in alcohol, ether, and chloroform.
While to the general public, Capsaicin is simply the chemical name for various forms of cayenne peppers, the biomedical community has recognized that Capsaicin provides a mechanism of action which is of value in the treatment of rheumatoid arthritis, osteoarthritis, certain forms of neuralgias and diabetic neurophepy. Commercial forms of Capsaicin exist as arthritis creams which are applied topically to joints where painful arthritis exists.
Park, et al, in
Cancer Letters
(1977), 114 (1,2), 183-184, AN 1997:223231 CAPLUS). Dm 126:260335, teach use of Capsaicin, in rats, as a prophylaxis, that is, as a preventative measure to lower the incidence of skin cancer, not to treat an existing lesion, that is, a lesion that has already come into existence as do the within inventors. In Parks, Capsaicin is applied entirely to nonnal (albeit non-human) epithelial tissue.
To the knowledge of the inventors, no other bio-medical applications of the botanical substance Capsaicin are known in the art. The present invention therefore relates to a dermatological use of Capsaicin having particular application in the treatment of pre-malignant tumors, this as is more fully set forth below.
SUMMARY OF THE INVENTION
The instant invention relates to a method of treating pre-malignant lesions, consisting of application of Capsaicin to pre-malignant lesions of the epithelium, this pre-malignant including basal and squamous cell lesions. Thereby, advantageous treatment, including atrophication and decoloration of such lesions, is accomplished. The Capsaicin, which is applied topically, is employed in a potency, or concentrations of at least 0.010% (w/w), with an average potency, or concentrations of 0.035% (w/w). Aloe vera may be employed in combination with the Capsaicin.
It is an object of the present invention to provide a new use of the botanical substance Capsaicin having particular reference to treatment of lesions of the skin to prevent them from becoming malignant.
It is another object to provide a biomedical use of Capsaicin by which topical tumors, scales and lesions can be substantially dissipated before their transformation into basal or squamous cell malignancies.
It is a further object to provide a means of prevention of cancers of the skin.
The above and yet other objects and advantages of the present invention will become apparent from the hereinafter set forth Detailed Description of the Invention and claims appended herewith.
BRIEF DESCRIPTION OF THE DRAWINGS
There are no drawings in this application.
DETAILED DESCRIPTION OF THE INVENTION
Certain scale-like lesions of the skin (clinically termed heaped-up particles of the epithelium) have been identified as precursors of basal and squamous cell malignancies of the skin. The same comprise brown skin spots which are most common among older persons, particularly in Sunbelt areas of the country such as Florida, Texas, Arizona and California.
The within inventors have discovered, through observations of the action of their proprietary form of Capsaicin in the treatment of arthritis, that decoloration, atrophication and, in some cases, complete disappearance of such brown spots upon the skin is accomplished through the topical application of Capsaicin in potencies, or concentrations in a range of 0.010% to 0.200% (w/w), with an average potency, or concentrations of 0.035% (w/w).


REFERENCES:
Jang et al., J. Korean Med. Sci., 6(1), 31-6 Abstract Only, 1991.*
Park et al., 114(1,2), 183-184 Abstract Only, 1997.*
Ellison et al., J. Clin. Oncol., 15(8), 2974-2980 Abstract Only, 1991.

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