Method for treating peripheral atherosclerotic disease employing

Details Method for treating peripheral atherosclerotic disease employing Method for treating peripheral atherosclerotic disease employing

1990-10-18

1994-02-01

Stoll, Robert L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

514423, 514547, 514824, A62K 31675, A62K 3140, A62K 31225

Patent

active

H00012866

ABSTRACT:
A method is provided for treating peripheral atherosclerotic disease (arteriosclerosis obliterans) and/or intermittent claudication employing a cholesterol lowering drug such as an HMG CoA reductase inhibitor alone and/or an inhibitor of the enzyme squalene synthetase and optionally a pharmaceutical which reduces serum cholesterol by a mechanism other than inhibiting production of the enzyme HMG CoA reductase or the enzyme squalene synthetase, for example, probucol or gemfibrozil; employing an ACE inhibitor alone such as captopril or ceranapril; or a combination of a cholesterol lowering drug and an ACE inhibitor.

REFERENCES:
patent: 4046889 (1977-09-01), Ondetti et al.
patent: 4231938 (1980-11-01), Monghon et al.
patent: 4346227 (1982-08-01), Terahara et al.
patent: 4404144 (1983-09-01), Liang
patent: 4448784 (1984-05-01), Glamkowski et al.
patent: 4450171 (1984-05-01), Hoffman et al.
patent: 4452790 (1984-06-01), Karanewsky et al.
patent: 4499289 (1985-02-01), Baran et al.
patent: 4578400 (1986-03-01), Ohnishi et al.
patent: 4759923 (1988-07-01), Buntin et al.
The Merck Manual (1982, 14th ed.) pp. 551-555.
Biller et al, J. Med. Chem., 1988, vol. 31, No. 10, pp. 1869-1872.
McClard, R. W. et al, JACS, 1987, 109, 5544.
Goldschmidt et al, "Effect of captopril exposure on endothelium-dependent relaxation in rabbit aorta," F.A.S.E.B. Journal 3:A1195, 1989.
Costa et al, "Use of captopril to reduce serum lipids in hypertensive patients with hyperlipidemia," Am. J. Hyperten. 1:2219-2239, 1988.
Edelman, S. et al, "Hyperkalemia During Treatment with HMG CoA Reductase inhibitor," N. Engl. J. Med. (320, No. 18, 1919-1920, 1989).
Zorn, J. et al, "Prevention of Arteriosclerotic Lesions with Calcium Antagonists or captopril in Different Rat Hypertension Models," J. Cardiovasc. Pharmacol. vol. 12 (Suppl 6), 1988.
Semoya, N. et al, "Suppressive Effect of Captopril on Platelet Aggregation in Essential Hypertension," J. Cardiovasc. Pharmacol. 6:840-843, 1984.
Mizuno, K. et al "The effects of the angiotensin I-converting enzyme inhibitor, captopril, on serum lipoperoxides level and the renin-angiotensin-aldosterone and kallikrein-kinin systems in hypertensive patients," nippon Naibunpi Gakkai Zasshi, Feb. 20, 1984.
Mizuno, K. et al, "Acute effects of captopril on serum lipid peroxides level in hypertensive patients," Tohoku J. Exp. Med., May, 1984, 143(1) pp. 127-128.
Overturf, M. et al, Atherosclerosis, 59:283-299, 1986.
Cecil, Textbook of Medicine, 16 Ed., pp. 239 to 241.

Affiliated with

Also associated with

Rating

Method for treating peripheral atherosclerotic disease employing does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for treating peripheral atherosclerotic disease employing, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for treating peripheral atherosclerotic disease employing will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-572254