Method for treating pediatric high grade astrocytoma including b

Details Method for treating pediatric high grade astrocytoma including b Method for treating pediatric high grade astrocytoma including b

1997-07-29

1999-08-24

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

514183, A61K 3133

Patent

active

059422475

ABSTRACT:
There is disclosed a method for treating high grade astrocytoma, especially brain stem glioma, in a child by administering to a child in need of such treating an amount of temozolomide sufficient to achieve a clinical response. Preferred dosing schedules are provided.

REFERENCES:
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Newlands, British J. Cancer, 65(2), 287-292 (1992).
Bleehen et al, J. Clinical Oncology, 13(4), 910-913 (1994).
O'Reilly et al, European J. cancer, 29A, 940 (1993).
Stevens et al, J. Medicinal Chem., 27, 196-201 (1984).
Wang et al, J. Chem. Soc.-Chem. Comm., 1687-1688 (1994).
Newlands et al, The Charing Cross Hospital Experience with Temozolomide in Patients with Gliomas, European Journal of Cancer, vol. 32A, No. 13, pp. 2236-2241, Dec. 1996.

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