Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1993-05-24
1997-10-14
Jordan, Kimberly
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
514212, 514255, 514593, A61K 3155, A61K 31495, A61K 31175
Patent
active
056773447
ABSTRACT:
A method is provided for treatment of Parkinson's disease or controlling movement of a Parkinsonian patient by administering an ATP-sensitive potassium channel blocker, such as a sulfonyl urea, (for example, tolbutamide), or quinine.
REFERENCES:
Noma A. (1983), "ATP-regulated K.sup.+ channels in cardiac muscle" Nature 305: 147-148.
Kakei M. and Noma A. (1984) "Adenosine 5'-triphosphate-sensitive single potassium channel in the atrioventricular node cell of the rabbit heart," J. Physiol. 352: 265-284.
Ashcrfot, F.M. et al (1984), "Glucose induced closure of single potassium channels in isolated rat pancreatic .beta.-cells," Nature 312: 446-448.
Sturgess, N.C. et al (1985), "The sulphonylurea receptor may be an ATP-sensitive potassium channel," Lancet 8435: 474-475.
Standen, N.B. et al (1989), "Hyperpolarizing vasodilators activate ATP-sensitive K.sup.+ channels in arterial smooth muscle," Science 245: 177-180.
Mourre, C. et al (1989), "Antidiabetic sulfonylureas: localization of binding sites in the brain and effects on the hyperpolarization induced by anoxia in hippocampal slices," Brain Res. 486: 159-164.
Virsolvyl-Vergine, A. et al (1988), "An endogenous ligand for the central sulfonylurea receptor," FEBS Letters 242: 65-69.
Ungerstedt, U. (1971), "Striatal dopamine release after amphetamine or nerve degeneration revealed by rotational behaviour," Acta Physiol. Scand. Suppl. 367: 49-68.
Greenfield, S.A. et al (1984), "A noncholinergic function for acetylcholinesterase in the substantia nigra:behavioural evicence," Expt. Brain Res. 54: 513-520.
Hansen et al., "Tolbatamide in the Treatment of Parkinson's Disease A Double Blind Trial", Danish Medical Bulletin, Dec. 1965, vol. 12, No. 7-8, pp. 181-184.
Greenfield Susan A.
Levesque Denyse
E. R. Squibb & Sons Inc.
Jordan Kimberly
Rodney Burton
LandOfFree
Method for treating Parkinson's disease employing an ATP-sensiti does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for treating Parkinson's disease employing an ATP-sensiti, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for treating Parkinson's disease employing an ATP-sensiti will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1555837