Method for treating pain

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C514S012200, C514S051000, C514S277000, C514S851000, C536S026100, C536S025600, C424S045000, C424S427000, C128S898000, C623S004100, C606S107000

Reexamination Certificate

active

06881725

ABSTRACT:
The present invention is directed to a method of treating pain. The method comprises administering to a subject a pharmaceutical composition comprising an effective amount of a P2X receptor antagonist. The methods of the present invention are useful in reducing pain, such as traumatic pain, neuropathic pain, organ pain and pain associated with diseases. The P2X receptor antagonists particularly useful for this invention are mononucleoside polyphosphate derivatives or dinucleoside polyphosphate derivatives of general Formula I. The compounds of the present method can be used alone to treat pain. The compounds of the present method can also be used in conjunction with other therapeutic agents or adjunctive therapies commonly used to treat pain, thus enhancing the overall pain-reducing effect in a subject in need of such treatment.

REFERENCES:
patent: 6462028 (2002-10-01), Pendergast et al.
patent: 10059990 (1998-03-01), None
patent: WO 9803177 (1998-01-01), None
patent: WO 0030629 (2000-06-01), None
patent: WO 0145691 (2001-06-01), None
patent: WO 0216381 (2002-02-01), None
patent: WO 03000056 (2003-01-01), None
Chizh et al “P2X receptors and nociception.”, Pharmacol. Rev. 53(4): 553-568,2000.*
Burnstock, “Physiological and Pathological Roles of Purines: An Update,”Drug Dev. Res. 28:195-206 (1993).
Chizh and Illes, “P2X Receptors and Nociception,”Pharmacol. Rev. 53(4):553-568 (2000).
Collier et al., “The Adcominal Constriction Response and its Suppression by Analgesic Drugs in the Mouse,”Br. J. Pharmac. Chemother. 32:295-310 (1968).
Goodman & Gilman,The Pharmacologic Basis of Therapeutics, McGraw-Hill, p. 529 (1996).
Holton and Holton, “The capillary Dilator Substances in Dry Powders of Spinal Roots; a Possible Role of Aensoine Triphosphate in Chemical Transmission from Nerve Endings,”J. Physiol. (Lond.) 126:124-140 (1954).
Jarvis and Kowaluk, “Pharmacological Characterization of P2X3Homomeric and Heteromeric Channels in Nociceptive Signaling and Behavior,”Drug Development Res. 52:220-231 (2001).
Kim and Chung, “An experiemental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat,”Pain 50:355-363 (1992).
Lewis et al., “Coexpression of P2X2and P2X3receptor subunits can account for ATP-gated currents in sensory neurons,”Nature 377:432-435 (1995).
Maciewicz and Martin,Harrison's Principles of Internal Medicine, 12thEdition, Jean D. Wilson et al., editors, McGraw-Hill, Inc., New York, p. 93 (1991).
Zhong, et al. “Pharmacological and molecular characterization of P2X reeptors in rat pelvic ganglion neurons,”Br. J. Pharmacol. 125:771-781 (1998).
Burnstock, et al., “P2 Purinergic Receptors: Modulation of Cell Function and Therapeutic Potential,”Journal of Pharmacology and Experimental Therapeutics 295(3):862-869 (2000).
Ding, et al., “ATP, P2X receptors and pain pathways,”Journal of Automatic Nervous System 81:289-294 (2000).
European Search Report, issued Sep. 11, 2003.
Zatorski, et al., “Chemical Synthesis of Benzamide Adenine Dinucleotide: Inhibition of Inosine Monophosphate Dehydrogenase (Types I and II),”J. Med. Chem. 39:2422-2426 (1996).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Method for treating pain does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for treating pain, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for treating pain will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3407051

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.