Method for treating osteoporosis

Details Method for treating osteoporosis Method for treating osteoporosis

1995-11-17

1997-12-09

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

9,10-seco- cyclopentanohydrophenanthrene ring system doai

514168, A61K 3159

Patent

active

056961030

ABSTRACT:
A method for treating osteoporosis via administration of a compound of the formula, 1.alpha.-fluoro-25-hydroxy-16-ene-23-yne-26,27-hexafluorocholecalciferol, in an amount therapeutically effective to restore bone density to an asymptomatic level, without inducing hypercalciuria, hypercalcemia, or nephrotoxicity is provided.

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patent: 5622941 (1997-04-01), Knutson
Kobayashi, Chem.Pharm. Bull., vol. 36(10), pp. 4144-4147, 1988.
Dechant, K., "Calcitriol -A Review of its Use in the Treatment of Postmenopausal Osteoporosis and its Potential in Corticosteroid-Induced Osteoporosis", Drugs & Aging 5(4):300-317, 1994.
Shiuey, S., "Total Synthesis of 1a-Fluoro-25-hydroxycholecalciferol and -ergocalciferol", J. Org. Chem. . vol. 55, No. 1, 243-247, 1990.
Okano, Toshio, Biochemical and Biophysical Research Comunications, vol. 163, No. 3, pp. 1444-1449, 1989.

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