Method for treating or preventing ulcerative diseases by adminis

Details Method for treating or preventing ulcerative diseases by adminis Method for treating or preventing ulcerative diseases by adminis

1998-08-25

1999-04-06

Stockton, Laura L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514340, 514342, 514376, A61K 3142, A61K 31425, A61K 3144

Patent

active

058918981

ABSTRACT:
A method for the treatment or prevention of an ulcerative disease comprising administering to a patient an effective amount of an active compound in admixture with a pharmacologically acceptable carrier or diluent, wherein said active compound is a thia-or oxazolidinone compound of the following formula or a pharmacologically acceptable salt thereof: ##STR1## wherein W is sulfur or oxygen and X is --N(R.sup.3)--, or X is sulfur or oxygen and W is --N(R.sup.3)--; R.sup.3 is hydrogen, C.sub.1 -C.sub.6 alkyl or aralkyl; R.sup.4 and R.sup.5 are the same or different and each is hydrogen, C.sub.1 -C.sub.6 alkyl,aralkyl, aryl, 5- or 6-membered aromatic heterocyclic; R.sup.6 is hydrogen, C.sub.1 -C.sub.6 alkyl or aralkyl; and A is C.sub.2 -C.sub.6 alkylene.

REFERENCES:
patent: 4923886 (1990-05-01), Shiokawa et al.
patent: 5298516 (1994-03-01), Ishihara et al.

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