Method for treating oncological diseases

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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C435S196000

Reexamination Certificate

active

07612032

ABSTRACT:
A method to treat solid tumors and other oncological diseases consists of parenterally injecting an agent which destroy's blood's extracellular DNA into the systemic blood circulation of a cancer patient to slow down malignant. The agent is embodied in the form of a DNAse enzyme and, more particularly, as a bovine pancreatic DNAse. Doses from 50,000-250,000,000 Kunz units/day are injected for 5-360 days. A binding agent or an agent that modifies the chemical composition of the blood extracellular DNA is additionally injected into the blood. This modifying agent is preferably an enzyme-ribonuclease.

REFERENCES:
patent: WO 01/074905 (2001-10-01), None
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Ulrich & Friend “Toxicogenomics and drug discovery: will new technologies help us produce better drugs?” Nature, 2002, 1, 84-88.
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Shak et al. “Recombinant human DNAse I reduces the viscosity of cystic fibrosis sputum,” Proc. Natl. Acad. Sci., 1990, 87, 9188-9192.
Leland et al. “Cancer chemotherapy—ribonucleases to the rescue” Chem. & Bio., 2001, 8, 405-13.
Nestle & Roberts “An extracellular nuclease from Serratia marcescens,” J. Biol. Chem., 1969, 244, 5213-5218.

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