Method for treating ocular hypertension and glaucoma

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai

Reexamination Certificate

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C514S903000

Reexamination Certificate

active

07074827

ABSTRACT:
Provided is a method for treating ocular hypertension and glaucoma with reduced side effects such as keratoconjunctive disorders and macular edema, which comprises administering an ophthalmic composition comprising latanoprost as an active ingredient thereof to a subject in need of said treatment, wherein the ophthalmic composition contains substantially no benzalkonium chloride.

REFERENCES:
patent: 2002/0103255 (2002-08-01), Hellberg et al.
patent: 2003/0018079 (2003-01-01), Richardson et al.
patent: WO 01/95913 (2001-12-01), None
patent: WO 02/38158 (2002-05-01), None
patent: WO 2004/022063 (2004-03-01), None
Costagliola, Ciro, et al., “Ocular surface changes induced by topical application of latanoprost and timolol: a short-term study in glaucomatous patients with and without allergic conjunctivitis” Graefe's Arch Clin Exp Ophthalmol (2001), 239: pp. 809-814. XP-002272140.
Noda, Eiichiro, et al., “Blood-aqueous barrier disruption and increment of cystoid macular edema incidence detected by fluorescent angiography caused by ophthalmic solution containing timololol and a preservative thereof in early postoperative pseudophakes”, Th 105thAnnual Meeting of the Japanese Ophthalmology Society, Apr. 19-21, 2001, Place: Pacifico Yokohana.
Xalatan, Pharmacia & Upjohn (4 pages), revised Nov. 2000.
International Search Report.

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