Method for treating non-small cell lung cancer, head and neck ca

Details Method for treating non-small cell lung cancer, head and neck ca Method for treating non-small cell lung cancer, head and neck ca

1987-10-23

1989-08-01

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Inorganic active ingredient containing

Heavy metal or compound thereof

514 34, 514262, 514260, 514110, 514281, 514274, A61K 3166, A61K 3144, A61K 3324, A61K 3170, A61K 31505, A61K 3152

Patent

active

048532215

ABSTRACT:
5-Methyl-6-[[(3,4,5-trimethoxyphenyl)amino]-methyl]-2,4-quinazolinediamine (trimetrexate) has been shown to possess clinical activity against non-small cell lung cancer, head and neck squamous cancers, and breast cancer. The compound also demonstrates therapeutic synergy with several known antineoplastic agents. Methods of treating non-small cell lung cancer, head and neck cancers, and breast cancer by administering trimetrexate alone or in combination with other neoplastic agents is disclosed.

REFERENCES:
patent: 4376858 (1983-03-01), Colbry
patent: 4391809 (1983-07-01), Elslager

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