Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1997-07-15
1999-10-12
Reamer, James H.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
A61K 3114
Patent
active
059655674
ABSTRACT:
The present invention relates to methods for treating nicotine addiction. The method involves administering to the patient an effective amount of a compound having the formula: ##STR1## wherein R.sup.1 is selected from the group consisting of hydrogen and C1 to C6 alkyl;
REFERENCES:
patent: 3372165 (1968-03-01), Archer
patent: 5512578 (1996-04-01), Crain et al.
Chemical Abstracts No. 72:119804 (1970).
Ator et al., "Nicotine Self-Administration in Baboons," Pharmacology, Biochemistry & Behavior, 19:993-1003 (1983).
Goldberg et al., "Control of Behavior by Intravenous Nicotine Injections in Laboratory Animals," Immunology Biochemistry & Behavior, 19:1011-1020 (1983).
Henningfield et al., "Control of Behavior by Intravenous Nicotine Injections in Human Subjects," Immunology Biochemistry & Behavior, 19:1021-1026 (1983).
Henningfield et al., "Nicotine as a Reinforcer in Human Subjects and Laboratory Animals," Pharmacology, Biochemistry & Behavior, 19:989-992 (1983).
Slifer, "Schedule-Induction of Nicotine Self-Administration," Pharmacology, Biochemistry & Behavior, 19:1005-1009 (1983).
Chemical Abstracts No. 102:125089 (1985).
Brazell et al., "Acute Administration of Nicotine Increases the In Vivo Extracellular Levels of Dopamine, 3,4-Dihydroxyphenylacetic Acid and Ascorbic Acid Preferentially in the Nucleus Accumbens of the Rat: Comparison with Caudate-Putamen," Neuropharmacology, 29:1177-1185 (1990).
Corrigall et al., "Selective Dopamine Antagonists Reduce Nicotine Self-Administration," Psychopharmacology,104:171-176 (1991).
Huston-Lyons et al., "Effects of Nicotine on the Threshold for Rewarding Brain Stimulation in Rats," Pharmacology, Biochemistry and Behavior, 41:755-759 (1992).
Malin et al., "The Nicotinic Antagonist Mecamylamine Precipitates Nicotine Abstinence Syndrome in the Rat," Psychophamacology, pp. 180-184 (1994).
Fink et al., "Clinical Status of the Narcotic Antagonists in Opiate Dependence," Antagonist and Antagonist Action of Narcotic Analgesic Drugs. Proceedings of an International Symposium, Aberdean, Scotland, Jul. 1971, Baltimore, MD:University Park Press, pp. 266-276 (1993).
Nisell et al., "Systemic Nicotine-Induced Dopamine Release in the Rat Nucleus Accumbens Is Regulated by Nicotinic Receptors in the Ventral Tegmental Area," Nicotine-Induced Dopamine Release, Synapse 16:36-44 (1994).
Gessner in Essentials of Pharmacology, Smith et al., eds, Philadelphia:W.B. Saunders, pp. 506-523 (1995).
Henningfield, "Nicotine Medications for Smoking Cessation," The New England Journal of Medicine, 333:1196-1202 (1995).
Archer et al., "Cyclazocine Revisited," Neurochemical Research, 21:1369-1373 (1996) (I).
Archer et al., "Suppression of Morphine and Cocaine Self-Administration in Rats by a Mixed Mu Antagonist-Kappa Agonist (N-CBM-TAMO) and a Long-Acting Selective D.sub.1 Antagonist (AS-300)," Bioorganic & Medicinal Chemistry Letters, 6:1139-1144 (1996) (II).
Glick et al., "An Oral Self-Administration Model of Nicotine Preference in Rats: Effects of Mecamylamine," Psychopharmacology, 128:426-431 (1996).
Dworkin et al., "Nicotine Self-Administration in Long-Evans Rats," CPDD Annual Meeting, Nashville, TN., (1997).
Glaxo Wellcome Inc., "Zyban (TM) (bupropion hydrochloride) Sustained-Release Tablets Now Available by Prescription," PRNewswire, Research Triangle Park, N.C. (1997).
Pich et al., "Common Neural Substrates for the Addictive Properties of Nicotine and Cocaine," Science, 275:83-86 (1997).
Archer Sydney
Glick Stanley D.
Albany Medical College
Archer Daniel
Archer David
Archer Eve
Reamer James H.
LandOfFree
Method for treating nicotine addiction does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for treating nicotine addiction, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for treating nicotine addiction will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-652741